ID R8VSV9_9CLOT Unreviewed; 1009 AA.
AC R8VSV9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00013303};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=HMPREF1526_03081 {ECO:0000313|EMBL:EOQ35613.1};
OS Butyricicoccus pullicaecorum 1.2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Butyricicoccus.
OX NCBI_TaxID=1203606 {ECO:0000313|EMBL:EOQ35613.1, ECO:0000313|Proteomes:UP000013981};
RN [1] {ECO:0000313|EMBL:EOQ35613.1, ECO:0000313|Proteomes:UP000013981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1.2 {ECO:0000313|EMBL:EOQ35613.1,
RC ECO:0000313|Proteomes:UP000013981};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Van Immerseel F., Eeckhaut V.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Butyricicoccus pullicaecorum 1.2.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOQ35613.1}.
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DR EMBL; AQOB01000015; EOQ35613.1; -; Genomic_DNA.
DR RefSeq; WP_016149166.1; NZ_KB976105.1.
DR AlphaFoldDB; R8VSV9; -.
DR PATRIC; fig|1203606.4.peg.3040; -.
DR eggNOG; COG3250; Bacteria.
DR HOGENOM; CLU_002346_0_2_9; -.
DR OrthoDB; 9762066at2; -.
DR Proteomes; UP000013981; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000013981}.
FT DOMAIN 738..1006
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1009 AA; 114984 MW; C49E79BCCD100BB4 CRC64;
MNLPTYNEDP AVLHVGTIEN HAYFIPFSDE ESARTHDRTR SARMTLLSGT WRFAYYPNQW
DVPDAFKEAD FDADSWDAIP VPSCWQMLGY DRHQYTNIRY PFPFDPPYVP EDNPCGAYVT
DFTLDTPDDV TELHFEGVDS CFYVWVNGNL VGYSQVSHST SAFDISAFVH AGRNRLAVLV
MKWCDGSYLE DQDKLRMSGI FRDVYLLHRP QHHIFDYTVR TPVSDDLREA AIDLSVVWND
APGQAMCTLY APDGTLLAQQ PTDTSGSVHF ALDHPVLWNA EHPALYELVI CADGETIVQQ
VGVKHIAVRD AVLYVNGVNI KIKGVNRHDS DPFVGYAVGR EHVLRDLRMM KQHNFNALRT
SHYPNAPWLP ELCARMGFYM IAEADLETHG AFSIYNSQPY AEGEFDYERE HPSFGMLCHD
PGFADAMLDR VQRSVIRDKN CAAILMWSLG NESGFGPNLE RAAHWVKTYD PTRLTHYESS
IYYLPDKPND LSDIDVYSRM YSSPAACDMY CEEDVVQKPF VQCEFVHAMG NGPGDIEDYF
ARIYRYDQFM GGFVWEWCDH AVWMGKTPEG KDRYFYGGDF GEFPHDGNFC MDGLVYPDRT
PHTGLKEWKN AARPVRAQWK SDDIGRVTLK NCLDFTDLCD AVTLRYEVTQ DGAVTQSGTC
DLPSIHPHTE AELNLPLCIP QTGTCCVNLY YLQKQADGVH EVGEELGFDQ YVVRREQPKQ
PEKASSAVTW QEDRRMVIVT GADFRYVWNR CTGLFDEMTA GQMTYCKQPQ QWNIWRAPTD
NDREIAPVWR QAGYDRALVR VYDSGVRQTE DGIELWANAA LNAIHIQHIV DLTVCWTIMG
DGSVHLRVDG KRNGQMPFLP RFGLRLFLPH DFETVDYLGY GPLESYIDKH QASKFGRYRA
TVTSLHEDYI KPQENGSHYG CTRLEIASDR GAAIAVTGDS FSFNASHYTQ EELEHKAHNF
ELTPCDATVL CLDYKMSGVG SNSCGPKLAE AYQLCETQFT WELDLRLGR
//
