ID   R8W010_9CLOT            Unreviewed;       193 AA.
AC   R8W010;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Thiamine-phosphate pyrophosphorylase {ECO:0000313|EMBL:EOQ37881.1};
GN   ORFNames=HMPREF1526_00905 {ECO:0000313|EMBL:EOQ37881.1};
OS   Butyricicoccus pullicaecorum 1.2.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Butyricicoccus.
OX   NCBI_TaxID=1203606 {ECO:0000313|EMBL:EOQ37881.1, ECO:0000313|Proteomes:UP000013981};
RN   [1] {ECO:0000313|EMBL:EOQ37881.1, ECO:0000313|Proteomes:UP000013981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1.2 {ECO:0000313|EMBL:EOQ37881.1,
RC   ECO:0000313|Proteomes:UP000013981};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Van Immerseel F., Eeckhaut V.,
RA   Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA   Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Butyricicoccus pullicaecorum 1.2.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004948}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOQ37881.1}.
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DR   EMBL; AQOB01000004; EOQ37881.1; -; Genomic_DNA.
DR   AlphaFoldDB; R8W010; -.
DR   PATRIC; fig|1203606.4.peg.871; -.
DR   eggNOG; COG0352; Bacteria.
DR   HOGENOM; CLU_018272_3_4_9; -.
DR   OrthoDB; 9815348at2; -.
DR   Proteomes; UP000013981; Unassembled WGS sequence.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00564; TMP_TenI; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR036206; ThiamineP_synth_sf.
DR   InterPro; IPR022998; ThiamineP_synth_TenI.
DR   PANTHER; PTHR20857:SF15; THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME; 1.
DR   PANTHER; PTHR20857; THIAMINE-PHOSPHATE PYROPHOSPHORYLASE; 1.
DR   Pfam; PF02581; TMP-TENI; 1.
DR   SUPFAM; SSF51391; Thiamin phosphate synthase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000013981};
KW   Thiamine biosynthesis {ECO:0000256|ARBA:ARBA00022977}.
FT   DOMAIN          8..184
FT                   /note="Thiamine phosphate synthase/TenI"
FT                   /evidence="ECO:0000259|Pfam:PF02581"
SQ   SEQUENCE   193 AA;  20631 MW;  139AA9D407253C80 CRC64;
     MSMFDRVLAV TNRKLCQGDF LAQIEHIAAA HPAGLVLREK DLDESAYRVL AGDVLRICDA
     HSVPCMLHRF DAVARALGCP RIHLPLPYLR EHPQAAQGFE TVGVSVHSTD EAKEAVQLGA
     TYLTAGHVFL TDCKKGVPAR GLDFLRAVCD AVSVPVYAIG GITPQNAPDC LAAGASGVAV
     MSGVMNRLSD WNI
//