ID R9AF78_WALI9 Unreviewed; 267 AA.
AC R9AF78;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 03-MAY-2023, entry version 37.
DE RecName: Full=ER membrane protein complex subunit 3 {ECO:0000256|ARBA:ARBA00020822, ECO:0000256|PIRNR:PIRNR010045};
GN ORFNames=J056_000632 {ECO:0000313|EMBL:EOR00822.1};
OS Wallemia ichthyophaga (strain EXF-994 / CBS 113033).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=1299270 {ECO:0000313|EMBL:EOR00822.1, ECO:0000313|Proteomes:UP000014064};
RN [1] {ECO:0000313|Proteomes:UP000014064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-994 / CBS 113033 {ECO:0000313|Proteomes:UP000014064};
RX PubMed=24034603; DOI=10.1186/1471-2164-14-617;
RA Zajc J., Liu Y., Dai W., Yang Z., Hu J., Gostincar C., Gunde-Cimerman N.;
RT "Genome and transcriptome sequencing of the halophilic fungus Wallemia
RT ichthyophaga: haloadaptations present and absent.";
RL BMC Genomics 14:617-617(2013).
CC -!- FUNCTION: The EMC seems to be required for efficient folding of
CC proteins in the endoplasmic reticulum (ER).
CC {ECO:0000256|PIRNR:PIRNR010045}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the EMC3 family. {ECO:0000256|ARBA:ARBA00005376,
CC ECO:0000256|PIRNR:PIRNR010045}.
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DR EMBL; KE007233; EOR00822.1; -; Genomic_DNA.
DR RefSeq; XP_009268535.1; XM_009270260.1.
DR AlphaFoldDB; R9AF78; -.
DR STRING; 1299270.R9AF78; -.
DR GeneID; 20373584; -.
DR KEGG; wic:J056_000632; -.
DR eggNOG; KOG3188; Eukaryota.
DR HOGENOM; CLU_060791_0_0_1; -.
DR OMA; KDMDPRW; -.
DR OrthoDB; 167603at2759; -.
DR Proteomes; UP000014064; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008568; EMC3.
DR InterPro; IPR002809; EMC3/TMCO1.
DR PANTHER; PTHR13116:SF5; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3; 1.
DR PANTHER; PTHR13116; UNCHARACTERIZED; 1.
DR Pfam; PF01956; EMC3_TMCO1; 1.
DR PIRSF; PIRSF010045; DUF850_TM_euk; 1.
DR SMART; SM01415; DUF106; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014064};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 97..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 267 AA; 30201 MW; 47D9547268AB1FFE CRC64;
MALTLNTPSL YIDDQIRDWV LFPITLVMIL VGLLRHYVVQ LLGGKGKKQE VKGIREQRAL
MRSAMLRKNG GVLTPTAFFK RKQFLIEAFK QGSYLKQAPP KDGEQQHPPN PLNDPEQMDS
MMDGMKKQMV MFIPQTVIMG WINSFFSGFI LIKLPFPLTR GFKSMLQRGI MTDDMPASYV
SSISWYFLNL FGLNSVLRLI LGEGNHADGV RDMQTAAQLA GTSSQPNPMQ NQDMNKVFKA
EIDNLELCEP KFMMSGVGNR VLEKYNG
//
