ID R9APN5_WALI9 Unreviewed; 609 AA.
AC R9APN5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Putative uroporphyrinogen-III C-methyltransferase {ECO:0000313|EMBL:EOR04015.1};
GN ORFNames=J056_002093 {ECO:0000313|EMBL:EOR04015.1};
OS Wallemia ichthyophaga (strain EXF-994 / CBS 113033).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=1299270 {ECO:0000313|EMBL:EOR04015.1, ECO:0000313|Proteomes:UP000014064};
RN [1] {ECO:0000313|Proteomes:UP000014064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-994 / CBS 113033 {ECO:0000313|Proteomes:UP000014064};
RX PubMed=24034603; DOI=10.1186/1471-2164-14-617;
RA Zajc J., Liu Y., Dai W., Yang Z., Hu J., Gostincar C., Gunde-Cimerman N.;
RT "Genome and transcriptome sequencing of the halophilic fungus Wallemia
RT ichthyophaga: haloadaptations present and absent.";
RL BMC Genomics 14:617-617(2013).
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the precorrin
CC methyltransferase family. {ECO:0000256|ARBA:ARBA00035662}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE007225; EOR04015.1; -; Genomic_DNA.
DR RefSeq; XP_009266232.1; XM_009267957.1.
DR AlphaFoldDB; R9APN5; -.
DR STRING; 1299270.R9APN5; -.
DR GeneID; 20375045; -.
DR KEGG; wic:J056_002093; -.
DR eggNOG; KOG1527; Eukaryota.
DR HOGENOM; CLU_011276_2_2_1; -.
DR OMA; IECTVVP; -.
DR OrthoDB; 296644at2759; -.
DR Proteomes; UP000014064; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR GO; GO:0000103; P:sulfate assimilation; IEA:InterPro.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR012066; Met1_fungi.
DR InterPro; IPR028162; Met8_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR PANTHER; PTHR45790:SF6; UROPORPHYRINOGEN-III C-METHYLTRANSFERASE; 1.
DR Pfam; PF13241; NAD_binding_7; 1.
DR Pfam; PF14823; Sirohm_synth_C; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036555; SUMT_yeast; 1.
DR SUPFAM; SSF75615; Siroheme synthase middle domains-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Reference proteome {ECO:0000313|Proteomes:UP000014064};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 244..282
FT /note="Siroheme biosynthesis protein Met8 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14823"
FT DOMAIN 323..528
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 609 AA; 66046 MW; 6954457DF9D83D4B CRC64;
MYKSPAGHGS LLIALNSTNK SLIVIGHNSL AASRSFAGLD AGCNVVVIGC GLDSACDEIK
FRVSADQIEY LTATSHSQLE AAFRSCCTRT STTIATITDC GINDSHDNSP SIHSLVQLSH
SLNIPINVTD HPLLCDFSFP TSHRFSLPDG SPSPLQLAVT TNSKGCRLAS RIKRETIALL
PKNIGSAVHN IGLLRSRAKR YLSRMKLERT TSQSSLSEEL ADFDNLNAAV PQLSRDNTTE
HASDKALRRM RWVAQISEYW PLEHLAKMDE ADIDSLLDAY GEPHQPRTPK TEFVPQWPLP
PPHDRHALSL APPQSPKPRK GHIVLVGAGL GSPELLTIAA YRALKTADLV LSDKLVPAAV
LKVVPQSTEV RIARKFPGNA EGAQAELMQW AVDGARSGQV VVRLKQGDPF VYGRGGEEVI
HFRREGYEAV VVPGLSSAMA APLMGGIPVT QRGASDSFLL CTGVGRGGRV LSVPEYARAR
TLTILMGVAR LRELVESLAQ LSYPPFVPVA VIEQASSPSQ RVVMSTLDGI VKAYEGAGDQ
RPPGMIVVGW SILSLHGEHG DLSVLDEDAE KHDQERVHRW LNGKLSIITE GPGRAWDEWL
KEVERPVVL
//
