ID R9B2P6_9GAMM Unreviewed; 1189 AA.
AC R9B2P6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=I593_02535 {ECO:0000313|EMBL:EOR06666.1};
OS Acinetobacter tandoii DSM 14970 = CIP 107469.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1120927 {ECO:0000313|EMBL:EOR06666.1, ECO:0000313|Proteomes:UP000016201};
RN [1] {ECO:0000313|EMBL:EOR06666.1, ECO:0000313|Proteomes:UP000016201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 107469 {ECO:0000313|EMBL:EOR06666.1,
RC ECO:0000313|Proteomes:UP000016201};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter tandoii CIP 107469.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOR06666.1}.
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DR EMBL; AQFM01000039; EOR06666.1; -; Genomic_DNA.
DR RefSeq; WP_016167572.1; NZ_KE007367.1.
DR AlphaFoldDB; R9B2P6; -.
DR PATRIC; fig|1120927.3.peg.2468; -.
DR eggNOG; COG0587; Bacteria.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000016201; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR048472; DNA_pol_IIIA_C.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR049821; PolIIIA_DnaE1_PHP.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF20914; DNA_pol_IIIA_C; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..71
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1189 AA; 133740 MW; 844DFA5B5A1082DD CRC64;
MHFVHLGIHT EFSITESIVR IPDLIKAAVN DEMPALALTD LSNLHAAVKF YGSCLSKGIK
PILGSVIRLN DAEHRVTLLA MTNQGWRGLT EIVSRGYIEG QQLDIPCVQK DWVLEQHQDI
IALLGMHSDV GKMLCSSNPQ KAEPLLEQWI EKFGNRVYLA LTRTDRPFEE DYIVEAVKLA
KKYNIGVVAH NDVHFITRED FEAHEARVCI ADGYVLGDDR RPKPYSPEQY FKTAAEMTEQ
FSDVPTAIEN SFHIARRCNV TLQLGKYFLP DYPIPEGHTI DTFFEHLSKE GLEERLNHLY
PVEQRGDDWA EIRKPYDERI NYEINIINSM GFPGYFLIVM DFIQWSKNNG VPVGPGRGSG
AGSLVAYSLK ITDLDPLRYD LLFERFLNPE RVSMPDFDVD FCIAGRDKVI DYVARNYGRD
AVSQIATFGT MAAKGAIRDV ARVLGKSYGL ADRISKMIPT KPLGLSLEES IEAEPQLKDI
VTNPSNPDND DAAEIWEMAL KLEGITRNTG KHAGGVVIAP TKITDFSAVL CDADGTGRVA
QYDKDDVEAA GLVKFDFLGL RNLTVIEDAV QNINKHYPAE IPLDIANIPL DDKDAYLVFA
NANTTAVFQF ESVGMKKMLK EARPSKFEEI IAFVSLYRPG PMDLIPDFIH RMHGGEFEYL
HPLLEGVLEP TYGIMVYQEQ VMQAAQYCAG YTLGGADLLR RAMGKKKPEE MVKQRQIFIE
GAAKKDIDEA TANHIFDYME KFAGYGFNKS HAAAYALVAY QTAWLKAHYP AEFLSAVLSS
EMQNTDNVVF LIDDCRTNGL EVLPPSVNMS LYHFHATNET TIVYGLGAIK GVGEQAMQSV
IDSRLHDGPY KDLFDFCHRI DLKKINKRTL EALIRAGALD CLGIERSSLM AQLPEAVQAA
EQARSNRETG IMDLFGEVEE VQRKPAKPVK PWSDEVRLKG EKDTLGLYLT GHPIDVYRPE
LKSFIPAKIN ELTPTRRGVT TVFAGLVVDV ANFPNRVMIT LDDGTSRIEV SANHERFQRF
KDIIVNERVV VIEGEIYERE GFDRPMGRLT KAFSLNEIRQ KRANSIQIKL QADHLSKTLS
QDLQKILLPY CNVDLCNHIP VLLQLDYAYA SAELHFGMQW KVAPLDELLS KLRDYFGKEA
IYIEYQVKSK AAKAVNYEQA RPAQVPPPPA DLSMDEAMDL YQADVNQYS
//
