ID R9C6N8_9BACI Unreviewed; 410 AA.
AC R9C6N8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Methionine synthase {ECO:0000313|EMBL:EOR22846.1};
GN ORFNames=A499_15841 {ECO:0000313|EMBL:EOR22846.1};
OS Niallia nealsonii AAU1.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Niallia.
OX NCBI_TaxID=1202533 {ECO:0000313|EMBL:EOR22846.1, ECO:0000313|Proteomes:UP000014030};
RN [1] {ECO:0000313|EMBL:EOR22846.1, ECO:0000313|Proteomes:UP000014030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AAU1 {ECO:0000313|EMBL:EOR22846.1,
RC ECO:0000313|Proteomes:UP000014030};
RA Joshi C.G., Duggirala S.M., Nathani N.M., Bhatt V.D., KaPatel J.A.,
RA Parnerkar S.P.;
RT "Whole genome shotgun sequencing of Bacillus nealsonii AAU1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOR22846.1}.
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DR EMBL; ASRU01000194; EOR22846.1; -; Genomic_DNA.
DR AlphaFoldDB; R9C6N8; -.
DR PATRIC; fig|1202533.3.peg.3286; -.
DR Proteomes; UP000014030; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008705; F:methionine synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.10.196.10; Vitamin B12-dependent methionine synthase, activation domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR004223; VitB12-dep_Met_synth_activ_dom.
DR InterPro; IPR037010; VitB12-dep_Met_synth_activ_sf.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF02965; Met_synt_B12; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF56507; Methionine synthase activation domain-like; 1.
DR PROSITE; PS50974; ADOMET_ACTIVATION; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
PE 4: Predicted;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00346};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU00346}.
FT DOMAIN 1..105
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 118..410
FT /note="AdoMet activation"
FT /evidence="ECO:0000259|PROSITE:PS50974"
SQ SEQUENCE 410 AA; 46228 MW; 946293141EB9BBBB CRC64;
MIDLGIKVPP AELVSAIKKE QPNIVGLSGL LVKSAQQMVL TAADMKQAGI DVPILVGGAA
LSRKFTDTKI SREYDGLVLY AKDAMNGLSL ANQLTNQEEF SLLKQEHEKK KQTLLAMPTK
DYVKPVITGI KRKTIDPKAP VFVPQDTKKH IVTNYTIGHI KPYINKQMLL GHHLGLKGKI
DVLLKQKDEK AVQLNDMIEQ LLLEAEQNNW ILPKAVYRFY PAQSDGNKIY IYDPDDVSKR
LETFDFPRQE REPYLCLADY LKPIDSGVMD YVAFFAVTAG TGIRQAAEQL KRDGRFLESH
ALQSLALETA EGLAEFIHRQ IRDRWGFPDP TNFTMKERFA AKYQGQRFSF GYPACPELED
QKKLFRLLSP EDIGIILSEE CMMEPEASVS AMVFAHPDAR YFNVLSSSLS
//
