ID R9GS90_9SPHI Unreviewed; 790 AA.
AC R9GS90;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Tyrosine-protein kinase Wzc {ECO:0000313|EMBL:EOR94563.1};
DE EC=2.7.10.2 {ECO:0000313|EMBL:EOR94563.1};
GN ORFNames=ADIARSV_2161 {ECO:0000313|EMBL:EOR94563.1};
OS Arcticibacter svalbardensis MN12-7.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Arcticibacter.
OX NCBI_TaxID=1150600 {ECO:0000313|EMBL:EOR94563.1, ECO:0000313|Proteomes:UP000014174};
RN [1] {ECO:0000313|EMBL:EOR94563.1, ECO:0000313|Proteomes:UP000014174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MN12-7 {ECO:0000313|EMBL:EOR94563.1,
RC ECO:0000313|Proteomes:UP000014174};
RX PubMed=23846277;
RA Shivaji S., Ara S., Prasad S., Manasa B.P., Begum Z., Singh A.,
RA Kumar Pinnaka A.;
RT "Draft Genome Sequence of Arcticibacter svalbardensis Strain MN12-7T, a
RT Member of the Family Sphingobacteriaceae Isolated from an Arctic Soil
RT Sample.";
RL Genome Announc. 1:E00484-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOR94563.1}.
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DR EMBL; AQPN01000079; EOR94563.1; -; Genomic_DNA.
DR RefSeq; WP_016195395.1; NZ_AQPN01000079.1.
DR AlphaFoldDB; R9GS90; -.
DR STRING; 1150600.ADIARSV_2161; -.
DR PATRIC; fig|1150600.3.peg.2135; -.
DR eggNOG; COG0489; Bacteria.
DR eggNOG; COG3206; Bacteria.
DR OrthoDB; 9794577at2; -.
DR Proteomes; UP000014174; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EOR94563.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000014174};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EOR94563.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..114
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 586..737
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 790 AA; 89683 MW; E1861640BC0113FE CRC64;
MNNIENVPLS HFVEKEEESS SKNFGETILR YLYYWPLFLV CIISTLAVAY VYLHYAKPEY
LVKAKLLIKV EKDSPNSGST LNEIINPYQS GKSVENEIEI IKSRSIISQV VKNLDLWVNY
TEKKRIVDED LYGISPVKFY LKRNNTDFES KNLNIVIENS DFFSLKEDDG TVKRLSFNDS
FRNNFGSWRL SKTADFNKYI GKSIQINVTD PELATDKLLS RIKAAEINKN ASIVELTLQE
SVLKRGKDIL NQLIVQYNYA SAKEKDRVAG TALKFIDDRL SSLTGELNSV EKEVEGFRSS
RGLTDISSES KLYLENVKNN DDHLNEVDVQ LNVIRELERY VSSPDNVNGA TPSTIGISDP
GLTAYVSRLI DLQLQYQKLM GTLPEKNPAF DPLKQQISST KDAIKQNIRN IKSSLLSTRR
QLESFNSGFE GSIRSLPSDE RQLVSIQRQQ SIKENLYLYL LQKREEAALS HASTLAFSQT
VDSAYLDTYK KPLTYSLALV IGILIPSLLL FGKELFNNKI SSTEQIEHTG VPVTAELIYE
YSKSPIVVHN KSRFAIGEQF RSLRTNLLYL HEKKKSGRVT LVTSSISGEG KSFVTSNLGV
ALAASGRKTL ILELDLRKPK IAKNFNLQEG LGLSDFLKGH ASINQIITPS SMHPNLFFIG
TGTLPDNPSE LLEQIEIDEL VEWLRSDYDD ILIDTPPIFL VTDAMILSRL ADAALYVIRQ
NYSYKKHLNF IKKIYKEHKL PKLQVVFNAI QKRGDSRYGY EYYAAMSEHK KTNIHSIFRE
VSNRLLLSNT
//
