ID R9IIA8_9FIRM Unreviewed; 1637 AA.
AC R9IIA8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=SrtB family sortase {ECO:0000313|EMBL:EOS21670.1};
GN ORFNames=C806_04318 {ECO:0000313|EMBL:EOS21670.1};
OS Lachnospiraceae bacterium 3-1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=397288 {ECO:0000313|EMBL:EOS21670.1, ECO:0000313|Proteomes:UP000014188};
RN [1] {ECO:0000313|EMBL:EOS21670.1, ECO:0000313|Proteomes:UP000014188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3-1 {ECO:0000313|EMBL:EOS21670.1,
RC ECO:0000313|Proteomes:UP000014188};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 3-1.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the serine-aspartate repeat-containing protein
CC (SDr) family. {ECO:0000256|ARBA:ARBA00007257}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS21670.1}.
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DR EMBL; ASST01000026; EOS21670.1; -; Genomic_DNA.
DR STRING; 397288.C806_04318; -.
DR PATRIC; fig|397288.3.peg.4717; -.
DR eggNOG; COG4509; Bacteria.
DR eggNOG; COG4932; Bacteria.
DR HOGENOM; CLU_005033_0_0_9; -.
DR OrthoDB; 9804660at2; -.
DR Proteomes; UP000014188; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd05826; Sortase_B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR Gene3D; 2.40.260.10; Sortase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041033; Prealbumin-like.
DR InterPro; IPR005754; Sortase.
DR InterPro; IPR023365; Sortase_dom-sf.
DR InterPro; IPR009835; SrtB.
DR InterPro; IPR013552; Thioester_dom.
DR NCBIfam; TIGR03064; sortase_srtB; 1.
DR PANTHER; PTHR36108:SF13; COLOSSIN-B; 1.
DR PANTHER; PTHR36108; COLOSSIN-B-RELATED; 1.
DR Pfam; PF04203; Sortase; 1.
DR Pfam; PF17802; SpaA; 6.
DR Pfam; PF08341; TED; 1.
DR SUPFAM; SSF49478; Cna protein B-type domain; 1.
DR SUPFAM; SSF63817; Sortase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014188};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1637
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004483652"
FT TRANSMEM 1342..1364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1376..1399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..214
FT /note="Thioester"
FT /evidence="ECO:0000259|Pfam:PF08341"
FT DOMAIN 437..496
FT /note="Prealbumin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17802"
FT DOMAIN 654..728
FT /note="Prealbumin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17802"
FT DOMAIN 773..848
FT /note="Prealbumin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17802"
FT DOMAIN 1009..1078
FT /note="Prealbumin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17802"
FT DOMAIN 1123..1194
FT /note="Prealbumin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17802"
FT DOMAIN 1230..1287
FT /note="Prealbumin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17802"
FT REGION 1296..1333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1422..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1520
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR605754-1"
FT ACT_SITE 1618
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR605754-1"
SQ SEQUENCE 1637 AA; 178017 MW; D8DB250F4D42CA0A CRC64;
MVNMKKHGLK RLLALLLCAV CLCGVFPSQA SAASVGQKAS SWLGDQYVGS DGRHYYAPAP
YTYLVYNSDG TMDVRSSSGG SAYRHYMLTA SDGSSQQVYC VESGIAYNTS DNTYTSESGT
NSNYLNLLPA EARRGITLTT IYGWKPGASL PVSGINEDDY KMATQIILWE YQQQLRSDPS
SRHGNGQANA DQYFSVIAGR PAEKAYNWIL SQVASHSTVP SFTSTKKSEA PELELKWDTE
KKVYTLTVTD TNNLKIDLET LKGSGVSATR SGNKYTFTSK NMIMDPVTFE FRKDIPVAND
MLIWGRPGYQ TMMTGASDPV SFFVKIKTET YGTAKIVKTS EDGIVSGIPF QISGTDILGN
KVDETVTTGE NGQIKEKLLP GTYLVKELPV DRYVTPSAQY ATIESGQTAT VHFSNILKKF
RVHVVKSDAD TGAAQGDATL AGATYGIYNN GELVDTYTTG PDGSFMTRYY VCGDNWTVRE
IDPSTGYLLN DTVYEVGASP TLYEVELNTT ENQVKETVIY GNIQLVKHTD GLDPDVSGDE
NTDEPNEGVI ERPEAGAVFE VYLKAAGSYD AAKESERDLL TTDGDGFASS KMLPYGHYTV
HQVSGEEGKA FIPDFTVFVS SNGQTYSYIL NNRTITARLR VEKCDAETGN IIPMTGTGFQ
IRDLSTGELV TQEIYYPNPE TLDTFYVSDE GWLMLPEPLH TGDYELYEVA APYGYVLSSE
PVPFTIDGSE AVVTVTQHNM PQKGQLTITK TGEVFASVQE NGGLYQPVYE VMGLPGAVYD
VIADEDIYTG DGTLRAAKDA VVETLTTGED GTAQSGLLYL GRYRLEERQA PEGMVLNTQP
EYAELTYAGE TVEVTQTAVG LYDERQKVAV SLSKALETDE LFGLGMNEEY KDISFGLYAS
ANLTALDGSV IPAGGLLEVV SIDPNEAGGY GASFASDLPF GSYYVKERTT NSAYILPDTE
YPVVFEYAGQ EAALVQVLVN EGGAVPNDLL RGRVDGVKTG ENPDGGEDVK LAGAVMGLFK
PDTEEFTGKN ALLTVTTGED GSFAFENIPY GHWIVKEISS PALYTVSPEQ HHIYIGVDGQ
SIKIKVENTL IRGSVQVMKT EAVDEPSSVE KKDKDNNTFL RFLSGAVFDL YEDANGNKEF
DSEDTKIGTL KESDAGYHTA ENLLAKGYFV KESKAPEGYQ MDENAYYFEI TEDGQVAVVE
NSEAGCGFTN EAYRGNLKIT KDSSDGRKDG FAFEVKNADG SYCETFTSPK SGVIEVKGLR
VGIYTVTEIS NRASRDYIIP DAATVEVKAD ETATVQFFNE KPEKPETPDS PDNPKTPSNP
STPSTPSNPG KAVPQTGDDN FIFLYGGLLA LAVIGGGLSA AAYFKKGKHS RNTARAKTTC
IAVLSLCGLL ALGSGFLIVR DLSQYAESAG TYDGLAEHVE VPEQAGEPEE PGAEEETGRE
DSSAVLPVVD FEALRENGPD IIGWLSLPDT AINYPVTQTD NNEYYLHHLY DGTYNKVGCL
FADYENQADF SDRNTIIYGH NMRDGSMFAA LNEYGEQGYY DGHPQMYLVT PGGGYTMEIF
TTFVAEPGES GSDTSPWRLS WKDDGAYTTW LSEMADRSVV ETDVTVTSSD KVLTLSTCTP
GGKSRFIVMG KLASVND
//
