ID R9J5J5_9FIRM Unreviewed; 675 AA.
AC R9J5J5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Flagellar hook-associated protein 2 {ECO:0000256|RuleBase:RU362066};
DE Short=HAP2 {ECO:0000256|RuleBase:RU362066};
DE AltName: Full=Flagellar cap protein {ECO:0000256|RuleBase:RU362066};
GN ORFNames=C807_02871 {ECO:0000313|EMBL:EOS29485.1};
OS Lachnospiraceae bacterium 28-4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=397287 {ECO:0000313|EMBL:EOS29485.1, ECO:0000313|Proteomes:UP000014112};
RN [1] {ECO:0000313|EMBL:EOS29485.1, ECO:0000313|Proteomes:UP000014112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28-4 {ECO:0000313|EMBL:EOS29485.1,
RC ECO:0000313|Proteomes:UP000014112};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 28-4.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|RuleBase:RU362066}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000256|ARBA:ARBA00011255,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362066}.
CC Bacterial flagellum {ECO:0000256|RuleBase:RU362066}.
CC -!- SIMILARITY: Belongs to the FliD family. {ECO:0000256|ARBA:ARBA00009764,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS29485.1}.
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DR EMBL; ASSU01000025; EOS29485.1; -; Genomic_DNA.
DR AlphaFoldDB; R9J5J5; -.
DR STRING; 397287.C807_02871; -.
DR PATRIC; fig|397287.3.peg.3140; -.
DR eggNOG; COG1345; Bacteria.
DR HOGENOM; CLU_015182_0_0_9; -.
DR OrthoDB; 9776025at2; -.
DR Proteomes; UP000014112; Unassembled WGS sequence.
DR GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR GO; GO:0009424; C:bacterial-type flagellum hook; IEA:UniProtKB-UniRule.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR InterPro; IPR040026; FliD.
DR InterPro; IPR010809; FliD_C.
DR InterPro; IPR003481; FliD_N.
DR PANTHER; PTHR30288; FLAGELLAR CAP/ASSEMBLY PROTEIN FLID; 1.
DR PANTHER; PTHR30288:SF0; FLAGELLAR HOOK-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF07195; FliD_C; 1.
DR Pfam; PF02465; FliD_N; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum {ECO:0000256|ARBA:ARBA00023143,
KW ECO:0000256|RuleBase:RU362066};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU362066};
KW Reference proteome {ECO:0000313|Proteomes:UP000014112};
KW Secreted {ECO:0000256|RuleBase:RU362066}.
FT DOMAIN 10..105
FT /note="Flagellar hook-associated protein 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02465"
FT DOMAIN 400..663
FT /note="Flagellar hook-associated protein 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07195"
FT COILED 216..338
FT /evidence="ECO:0000256|RuleBase:RU362066"
FT COILED 619..646
FT /evidence="ECO:0000256|RuleBase:RU362066"
SQ SEQUENCE 675 AA; 75186 MW; EE752512A60D1E8D CRC64;
MPIRITGMNS GLDTESIISE LVKAQKTKVD SVKKKQTTIQ WKQDAWKELN AKIYKLFQNT
IGNMRLATDY SKKITDVSNS AIASVISGDN AMDATQKLKV EGLAKTGYMT GDKVEGDVTS
ESSLSDLGIK AGSTITVTTG GKSTDISITE DMTIGSFVNT LREAGVEASF DEKNKRFHIA
SKKSGEINNF SITAANEDGT DALKKLGILS YDEKTIKEYE KYNNMSEADI EEAVDQEVSS
RLKGYISQRE ELLKTKQKQN DALAESEKAF SEEYGADIKD VNKDDLKKEI DSLKTQIEDA
GEDATEEDKD KLAKLQGKLS AVEKYESQQK ELEETEKSIG KVESYLNLDD PANITASDTL
RTEVDQAWRA KIKTAHDIVE ESKKPDMGNL KGSNAKKIDG EDAHIVLNGV DYYGESNTFE
VNGLTITALQ ESSDEITLTT RRDTDGVYNI VKNFLKEYNS LINEMDKLYN AEAAKDYEPL
TDEEKKELSD SDVEKWETKI KDSILRRDSN LSTISSAMKN IMLQGATVNG KQMYLANFGI
ETLGYFSAAE NERNAYHING DEDDSAVSSK DNELKAAIAS DPDTVIAFFS QLSQNLYAEL
DRQSRSVEGI RSFGSFYDDK RMQEDYKDYA EKIKKQEARL TAMEDKWYKK FSAMETAMAK
MQSNQSAVSS LLGGM
//
