ID   R9J9H7_9FIRM            Unreviewed;       313 AA.
AC   R9J9H7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=GDP-mannose 4,6-dehydratase {ECO:0000313|EMBL:EOS30666.1};
GN   ORFNames=C807_02207 {ECO:0000313|EMBL:EOS30666.1};
OS   Lachnospiraceae bacterium 28-4.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=397287 {ECO:0000313|EMBL:EOS30666.1, ECO:0000313|Proteomes:UP000014112};
RN   [1] {ECO:0000313|EMBL:EOS30666.1, ECO:0000313|Proteomes:UP000014112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=28-4 {ECO:0000313|EMBL:EOS30666.1,
RC   ECO:0000313|Proteomes:UP000014112};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 28-4.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS30666.1}.
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DR   EMBL; ASSU01000016; EOS30666.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9J9H7; -.
DR   STRING; 397287.C807_02207; -.
DR   PATRIC; fig|397287.3.peg.2410; -.
DR   eggNOG; COG1089; Bacteria.
DR   HOGENOM; CLU_007383_1_7_9; -.
DR   OrthoDB; 9789543at2; -.
DR   Proteomes; UP000014112; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR43000:SF48; GDP-6-DEOXY-D-MANNOSE REDUCTASE; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   PRINTS; PR01713; NUCEPIMERASE.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014112}.
FT   DOMAIN          5..305
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   313 AA;  35277 MW;  A66A76D9F9FC0A5E CRC64;
     MKKALIIGAA GFVGGYLAGH LRERRGMEVS VTKLPREEFR GDSDRVYNLN ILNKEEIVSL
     LFEARPDYIF HLAAQSSVGV AWKNPSLTID INIKGSVNVM DAIRELYYKP RILLIGSGEE
     YGHIEEGEIP IREENRIRPG NIYAATKACQ NMIGNIYAQA YDMEVMMVRA FNHIGPSQAS
     IFVVSDFCRQ VAEIEKGIRE PVMYVGNLDA RRDFTDVRDV VEAYGLLAEH GRPGETYNVG
     RGKAVSIREI LDMVIALSGH DIKIEIDKNK LRPVDVPIIE ADISKISSLT GWKPKIPLKQ
     TIEETLNYWR RTI
//