ID   R9JU92_9FIRM            Unreviewed;       231 AA.
AC   R9JU92;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase {ECO:0000313|EMBL:EOS37794.1};
GN   ORFNames=C808_03774 {ECO:0000313|EMBL:EOS37794.1};
OS   Lachnospiraceae bacterium M18-1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235792 {ECO:0000313|EMBL:EOS37794.1, ECO:0000313|Proteomes:UP000014090};
RN   [1] {ECO:0000313|EMBL:EOS37794.1, ECO:0000313|Proteomes:UP000014090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M18-1 {ECO:0000313|EMBL:EOS37794.1,
RC   ECO:0000313|Proteomes:UP000014090};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium M18-1.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-
CC       erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
CC       {ECO:0000256|ARBA:ARBA00002459}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS37794.1}.
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DR   EMBL; ASSV01000027; EOS37794.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9JU92; -.
DR   STRING; 1235792.C808_03774; -.
DR   PATRIC; fig|1235792.3.peg.4075; -.
DR   eggNOG; COG1211; Bacteria.
DR   HOGENOM; CLU_061281_2_3_9; -.
DR   OrthoDB; 9806837at2; -.
DR   Proteomes; UP000014090; Unassembled WGS sequence.
DR   GO; GO:0070567; F:cytidylyltransferase activity; IEA:InterPro.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02516; CDP-ME_synthetase; 1.
DR   InterPro; IPR034683; IspD/TarI.
DR   InterPro; IPR018294; ISPD_synthase_CS.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR32125; 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR32125:SF4; 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC; 1.
DR   Pfam; PF01128; IspD; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   PROSITE; PS01295; ISPD; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:EOS37794.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014090};
KW   Transferase {ECO:0000313|EMBL:EOS37794.1}.
SQ   SEQUENCE   231 AA;  25581 MW;  16276EA44047D08E CRC64;
     MNIALILSGG TGTRLGSEIP KQYIKVCGKP VISYCIEILS AHEAIHAVHI VAESAWQEQI
     EFWMESDGLK QKFRGFSAPG ATRQLSIWNG LRDIGQYAIA SDCVLIHDAA RPMLSEKLIT
     DCLDKIQGHD GVIPVLPMKD TVYSSLDGRT ITSLLDRSSV YAGQAPEVFR LGKYYEANQR
     LLPEKIWKIS GSTEPAVAAG MEIAMIPGEE RNFKITTKED LERFLTLNEA K
//