ID R9JWP5_9FIRM Unreviewed; 678 AA.
AC R9JWP5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=MATE efflux family protein {ECO:0000313|EMBL:EOS38346.1};
GN ORFNames=C808_02547 {ECO:0000313|EMBL:EOS38346.1};
OS Lachnospiraceae bacterium M18-1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1235792 {ECO:0000313|EMBL:EOS38346.1, ECO:0000313|Proteomes:UP000014090};
RN [1] {ECO:0000313|EMBL:EOS38346.1, ECO:0000313|Proteomes:UP000014090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M18-1 {ECO:0000313|EMBL:EOS38346.1,
RC ECO:0000313|Proteomes:UP000014090};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium M18-1.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS38346.1}.
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DR EMBL; ASSV01000016; EOS38346.1; -; Genomic_DNA.
DR AlphaFoldDB; R9JWP5; -.
DR STRING; 1235792.C808_02547; -.
DR PATRIC; fig|1235792.3.peg.2732; -.
DR eggNOG; COG0534; Bacteria.
DR eggNOG; COG1102; Bacteria.
DR HOGENOM; CLU_012893_0_0_9; -.
DR Proteomes; UP000014090; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR CDD; cd13143; MATE_MepA_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR045070; MATE_MepA-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR Pfam; PF13189; Cytidylate_kin2; 1.
DR Pfam; PF01554; MatE; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014090};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 678 AA; 75000 MW; 1FAFBAA2710C653A CRC64;
MDKSLNSNII KQTETNILGY EKIGKLIRMY AIPSIISILV NALYNMVDQV FIGRGVGYLG
NGATNIVFPI TIVFASFALM FGDGSSAYLS LKLGENQKED AGIGVANGII SAVAISIIFT
AGVLLFLPQL LNLFGCTPNL EGYAKDYGYI ITIGLPFMMI GTTVNSIIRA DGNPKYAMIT
MVTGAILNVV LDPIFIFVFH WGVKGAATAT IISQIISFLL NIMYLGKLKT IRLKNHFKFS
FSVARKVSSL GISSFITQMS AALIIGLQNN LLKKYGAQSV YGPEIPLTVL GIVMKVNEIL
NSIVLGLAMG SQPIIGFNYG ARKYERVKKT LKVVIISSLT ISTVAFLLFQ TIPDKIIVLF
GSSTDLKYME FAKLSFRIYL LMIIGNGVQT PVGIFLQSIG KSAKSALLSM SKQVLFLVPG
MLLLGHVFGI NGVLYAKPVS EGLAFLLSIV LLVSELRLFG RAKSQSAALV GDADINHTLD
RPILITVSRE YGSGGRYIGK MIAERFGIRF YDKDIIIKLA EKTGLSEEYI ENHEQKRNLL
SGFNKGYYNG PNSGDELFIK ESEIIKEIAE QESCVIIGRC ADYILKDREN LVKVFIYSNM
EDKVKRAVTY YGLAQDKAEK EIRKNDRERA IHYKHYTDRD WTDRSNYDIC MNGDFLGVEK
TAELICAMVR EKLNIVEI
//
