ID   R9JY72_9FIRM            Unreviewed;       581 AA.
AC   R9JY72;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   SubName: Full=Dihydroxy-acid dehydratase {ECO:0000313|EMBL:EOS39140.1};
GN   ORFNames=C808_01995 {ECO:0000313|EMBL:EOS39140.1};
OS   Lachnospiraceae bacterium M18-1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235792 {ECO:0000313|EMBL:EOS39140.1, ECO:0000313|Proteomes:UP000014090};
RN   [1] {ECO:0000313|EMBL:EOS39140.1, ECO:0000313|Proteomes:UP000014090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M18-1 {ECO:0000313|EMBL:EOS39140.1,
RC   ECO:0000313|Proteomes:UP000014090};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium M18-1.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC       {ECO:0000256|ARBA:ARBA00006486}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS39140.1}.
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DR   EMBL; ASSV01000013; EOS39140.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9JY72; -.
DR   STRING; 1235792.C808_01995; -.
DR   PATRIC; fig|1235792.3.peg.2147; -.
DR   eggNOG; COG0129; Bacteria.
DR   HOGENOM; CLU_014271_4_2_9; -.
DR   OrthoDB; 9807077at2; -.
DR   Proteomes; UP000014090; Unassembled WGS sequence.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0016836; F:hydro-lyase activity; IEA:InterPro.
DR   GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.30.80; IlvD/EDD C-terminal domain-like; 1.
DR   InterPro; IPR042096; Dihydro-acid_dehy_C.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   InterPro; IPR037237; IlvD/EDD_N.
DR   PANTHER; PTHR43661; D-XYLONATE DEHYDRATASE; 1.
DR   PANTHER; PTHR43661:SF3; D-XYLONATE DEHYDRATASE YAGF-RELATED; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF143975; IlvD/EDD N-terminal domain-like; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
DR   PROSITE; PS00887; ILVD_EDD_2; 1.
PE   3: Inferred from homology;
KW   2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022714};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014090}.
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   581 AA;  63413 MW;  A566CFF8FA24C05D CRC64;
     MELRSQEMRK NAPELDPLRI GTGWKPEDLS KPQVMIESTF GDSHPGSGHL DILVEEVRKG
     IEEAEGHGAR YYCTDICDGE SQGTDGINYS LASREMIANM IEIHANATPF DAGVYLASCD
     KGLPGNLMGL ARVDVPAVVV PGGTMNAGPE MLTLEQLGMY SAKYQRGEID EEKLNWAKCN
     ACPSCGACSF IGTASTMQIM AEALGLALPG SALMPATSPD LLTFAREAGA QAVKLATMPG
     MRPSDIVTMD SFENAILVHA AVSGSTNCLL HIPAIAHEFG IEITGDTFDR LHRNARYLLD
     VRPAGRWPAE CFYYAGGVPA IMEEIKSHLH LDVMTVTGKT LGENLEELKK NGFYERCEKW
     LQEFNVRYHV SLKKEDIIRP YGEAIGTDGS IAILRGNLAP EGAVIKHTAC PKEMFKAVLR
     ARPFDSEEEC LDAVLKHKVE KGDAVFIRYE GPKGSGMPEM FYTSEAISSD KELGKSIALI
     TDGRFSGAST GPVIGHCSPE AVDGGPIALV EEGDLIEIDV EERKLNIIGI AGERRTMEEV
     AVVLEERRKN WKPREPKYKK GVLRLFSEHA ASPMKGAYLE Y
//