ID R9K2E9_9FIRM Unreviewed; 878 AA.
AC R9K2E9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=alpha-L-rhamnosidase {ECO:0000256|ARBA:ARBA00012652};
DE EC=3.2.1.40 {ECO:0000256|ARBA:ARBA00012652};
GN ORFNames=C808_00664 {ECO:0000313|EMBL:EOS40609.1};
OS Lachnospiraceae bacterium M18-1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1235792 {ECO:0000313|EMBL:EOS40609.1, ECO:0000313|Proteomes:UP000014090};
RN [1] {ECO:0000313|EMBL:EOS40609.1, ECO:0000313|Proteomes:UP000014090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M18-1 {ECO:0000313|EMBL:EOS40609.1,
RC ECO:0000313|Proteomes:UP000014090};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium M18-1.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing alpha-L-rhamnose residues
CC in alpha-L-rhamnosides.; EC=3.2.1.40;
CC Evidence={ECO:0000256|ARBA:ARBA00001445};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS40609.1}.
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DR EMBL; ASSV01000005; EOS40609.1; -; Genomic_DNA.
DR AlphaFoldDB; R9K2E9; -.
DR STRING; 1235792.C808_00664; -.
DR PATRIC; fig|1235792.3.peg.726; -.
DR eggNOG; COG3408; Bacteria.
DR HOGENOM; CLU_002926_0_1_9; -.
DR OrthoDB; 9815108at2; -.
DR Proteomes; UP000014090; Unassembled WGS sequence.
DR GO; GO:0030596; F:alpha-L-rhamnosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR035396; Bac_rhamnosid6H.
DR InterPro; IPR035398; Bac_rhamnosid_C.
DR InterPro; IPR013737; Bac_rhamnosid_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008902; Rhamnosid_concanavalin.
DR PANTHER; PTHR33307; ALPHA-RHAMNOSIDASE (EUROFUNG); 1.
DR PANTHER; PTHR33307:SF6; ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF05592; Bac_rhamnosid; 1.
DR Pfam; PF17389; Bac_rhamnosid6H; 1.
DR Pfam; PF17390; Bac_rhamnosid_C; 1.
DR Pfam; PF08531; Bac_rhamnosid_N; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000014090}.
FT DOMAIN 149..315
FT /note="Bacterial alpha-L-rhamnosidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08531"
FT DOMAIN 327..415
FT /note="Alpha-L-rhamnosidase concanavalin-like"
FT /evidence="ECO:0000259|Pfam:PF05592"
FT DOMAIN 429..796
FT /note="Alpha-L-rhamnosidase six-hairpin glycosidase"
FT /evidence="ECO:0000259|Pfam:PF17389"
FT DOMAIN 800..862
FT /note="Alpha-L-rhamnosidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17390"
SQ SEQUENCE 878 AA; 99578 MW; 5F8DBD6444F356D8 CRC64;
MLNILSGSVR LLEKPEFSWI LEGDEDQVCF KIRIKDAYGR LYWDSGEIVS GKRHNIVCDK
ALKDESIYTW SVRVQGAIGG TAEYQGGKIY TKISSWSAKW IEPDRVRKPL TDSMEPIEPV
AKGKVPGDSL EKLDPVTCFR KEFELPEVPA QALVYAASHG IYTLYMNGRR VSDLFAPGYT
SYEKHIDYQC YEVTDLLRTG KNVMAFELAD GWYTGKISAL GIGQQFGTEN AILGELILKN
PDGSRTAIIT DEGMRWSEGA LRYADLYIGE YYDSHYLKEG WEQPAFEMDH SWRAAVARDY
GYETLVMQTI PGIKEIRTIR PEILFAPNGD MLLDAGENIV GYVSFELDLK AGDIVSMEHS
ETLDKDGNYI QNIIGQNKDQ MDFYVASADG VAIYKPEFTF HGFRYVRVNG TKDADKEHYL
IHVIGTPLRK TGEFTCSDDR LNKLQEVICR SQLGNMISIP TDCPQRERTG WLGDMQVFAP
TGCYEYDIEE FLRHWLADIR NEQLPDGQIP HITPCMKSHD IMKPPGIKGV SAAGWSDAAV
IIPWRLYEAY GDINILKENF EMIKSYMAST EELAAELPAD YEELDDARKA VQKYLWNTGF
QYGDWLMPSI QMSGKPIFEV VAQTGYVVAT LMFMLTTDIT AKICDLLGES RLCRHYQELN
EKVREAFAVE YINADGTLSK DYQGIYVLAL KANAIPEELK PRAVQRLAEL IHENHDLLDT
GFLSVAYLLP VLKENGLKKL ANRLLFQDEC PSWLYEIKMG ATTMWEYWNG YAPDGTPSDC
SMNHFAFGCV GEYLFHDILG IQNTDPGRGI LEIEPDIDCG LTWVKGSYET VWGNCRVEWK
KESKHTALYL ELPPNVTAKV RIGEHIRTFG CGTHRMEV
//
