ID   R9K4B6_9FIRM            Unreviewed;       382 AA.
AC   R9K4B6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=AI-2E family transporter {ECO:0008006|Google:ProtNLM};
GN   ORFNames=C808_02493 {ECO:0000313|EMBL:EOS38292.1};
OS   Lachnospiraceae bacterium M18-1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235792 {ECO:0000313|EMBL:EOS38292.1, ECO:0000313|Proteomes:UP000014090};
RN   [1] {ECO:0000313|EMBL:EOS38292.1, ECO:0000313|Proteomes:UP000014090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M18-1 {ECO:0000313|EMBL:EOS38292.1,
RC   ECO:0000313|Proteomes:UP000014090};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium M18-1.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC       family. {ECO:0000256|ARBA:ARBA00009773}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS38292.1}.
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DR   EMBL; ASSV01000016; EOS38292.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9K4B6; -.
DR   STRING; 1235792.C808_02493; -.
DR   PATRIC; fig|1235792.3.peg.2675; -.
DR   eggNOG; COG0628; Bacteria.
DR   HOGENOM; CLU_031275_2_0_9; -.
DR   OrthoDB; 9793390at2; -.
DR   Proteomes; UP000014090; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002549; AI-2E-like.
DR   PANTHER; PTHR21716; TRANSMEMBRANE PROTEIN; 1.
DR   PANTHER; PTHR21716:SF75; TRANSPORT PROTEIN SLL0063-RELATED; 1.
DR   Pfam; PF01594; AI-2E_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014090};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        14..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        37..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        83..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        235..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        266..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        302..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   382 AA;  42383 MW;  43F4829C34182F84 CRC64;
     MDLNKENMRK IKELIVFTIV ILIALWKYTL VVDFLGFILN IIFPFLLGGA IAFILNVPMS
     FLESKIFGNK NIEGRPAQKF ARPCSLTLTI LGVIGIIALV MFVVIPQLGS TFVGLGKTIQ
     DFTPVAMAWI EELFHNNQEI MTLLEDFNMD WDKILDGFAA FFKNGAGSVL DTTMSAAKSI
     ISSVTTFFIA FVFSCYILLQ KEKLRVQVQK IFYAYLPKKI VEKVLDICSL TYRTFASFLA
     GQCVEALILG MMFLVTMWIL RLPYALLVGV LIAFTALIPI FGAFIGCIVG AFLILMVNPV
     KAITFVAMFL VLQQVEGNLI YPKVVGNSVG LPSIWVLAAV SIGGSLMGVV GMLVFIPLVS
     VVYILFRGDV YKRLEKKGIE LD
//