ID   R9K850_9FIRM            Unreviewed;      1011 AA.
AC   R9K850;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=DUF2726 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=C810_04393 {ECO:0000313|EMBL:EOS42523.1};
OS   Lachnospiraceae bacterium A2.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=397290 {ECO:0000313|EMBL:EOS42523.1, ECO:0000313|Proteomes:UP000014150};
RN   [1] {ECO:0000313|EMBL:EOS42523.1, ECO:0000313|Proteomes:UP000014150}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A2 {ECO:0000313|EMBL:EOS42523.1,
RC   ECO:0000313|Proteomes:UP000014150};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium A2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS42523.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ASSX01000031; EOS42523.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9K850; -.
DR   STRING; 397290.C810_04393; -.
DR   PATRIC; fig|397290.3.peg.4867; -.
DR   eggNOG; COG1112; Bacteria.
DR   HOGENOM; CLU_293363_0_0_9; -.
DR   OrthoDB; 9757917at2; -.
DR   Proteomes; UP000014150; Unassembled WGS sequence.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   CDD; cd17934; DEXXQc_Upf1-like; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR024402; DUF2726.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF10881; DUF2726; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014150}.
FT   DOMAIN          327..642
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          679..838
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
FT   DOMAIN          885..1001
FT                   /note="DUF2726"
FT                   /evidence="ECO:0000259|Pfam:PF10881"
SQ   SEQUENCE   1011 AA;  117410 MW;  9F53051FBF84F9B0 CRC64;
     MNTIHRDIFR AIHEGKWLSI EYRNREGQIS RYWIGIYGLD PARRTLKVEG LHLGKYTTKT
     YDLIYIDSIL SSSIVEGSYC PVNQKLVQDI YLNPQKYKGL FEHAVNLKIL NYLEMCNRMD
     TVPYYSDFEL VRYLDRESFH GTEYYLSEEQ FCMVVKHFQR KSQEKRGREG RQSIQQLAMN
     VLSIHTPRGL YALAYRKLQL DVKKRTLRPD DEIIICTEFT LDGVKEHVRK FLDAEDYELL
     KDFERNQEQI KECITSRGRQ PLAVDDMPYM IGLGMDILLD LHKEYESVIH MYQSHEVPAP
     IRAFFGEMVS RPIRRKAYPI VLADQKVNLD QLLAINNAMK YPVAYIQGPP GTGKTSTIIN
     TIVTAFFNEK TVLFVSYNNH PINGVAEKLL GMKYQGKAIP FPVLRLGSNE KMQEALEHME
     YVYQQVQSIQ VYEATLERDR DGRIVRARQL SGLLRRYEEL LDLKEREETI SRVLDFGDSQ
     DLSFQMLPFR ADLQGRQMEQ VRRRMGKTGN ITEEEAFALL DKNVEELKKY LYFTSAKYIK
     KLDLPRHKDL KKILQCRDKK ERLEEFSRYL GKKENIRKLQ EIFPVIATTC ISAHKLGEPA
     PMFDMVIMDE ASQCNTAVSL VPILRGSSLM MVGDPQQLNP VIQLEELVNQ KLRKKYGIPD
     EYDYRRNSIY KTYLACDAVS DEILLHYHYR CHEKIIGFNN QKYYNGKLCI KTESKEQEPL
     LYIDVADSQS NGKNTAGNEV EEIVKYALQN RDRTIGVITP FVNQKKLLEE ALAKAHLTNV
     DCGTVHAFQG DEKDIVLFST AVTAQTQAGT YAWLKNNKEL INVATSRARD KLIILSDMKN
     LERLHQQGNE DDLYELVQYA KRNGNSQVTQ KQANSRALGV KPFSTATEEA FLKNLNHALE
     NIWLSQNRFQ VQRGVAISEV LPGQEHMMHL FYADTFDFVV YEQQEGQEFP VLAIELEGRE
     HLGEETVRQR ELQKQQVCQT AGLQVIRVEN SYARRYNHIK EILVNFFSGK R
//