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Database: UniProt
Entry: R9K8A0_9FIRM
LinkDB: R9K8A0_9FIRM
Original site: R9K8A0_9FIRM 
ID   R9K8A0_9FIRM            Unreviewed;       556 AA.
AC   R9K8A0;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000256|HAMAP-Rule:MF_01543};
DE            EC=6.3.4.3 {ECO:0000256|HAMAP-Rule:MF_01543};
DE   AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000256|HAMAP-Rule:MF_01543};
DE            Short=FHS {ECO:0000256|HAMAP-Rule:MF_01543};
DE            Short=FTHFS {ECO:0000256|HAMAP-Rule:MF_01543};
GN   Name=fhs {ECO:0000256|HAMAP-Rule:MF_01543};
GN   ORFNames=C809_04616 {ECO:0000313|EMBL:EOS39697.1};
OS   Lachnospiraceae bacterium MD335.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235793 {ECO:0000313|EMBL:EOS39697.1, ECO:0000313|Proteomes:UP000014081};
RN   [1] {ECO:0000313|EMBL:EOS39697.1, ECO:0000313|Proteomes:UP000014081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COE1 {ECO:0000313|EMBL:EOS39697.1,
RC   ECO:0000313|Proteomes:UP000014081};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium COE1.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-
CC         formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216;
CC         EC=6.3.4.3; Evidence={ECO:0000256|HAMAP-Rule:MF_01543};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|HAMAP-Rule:MF_01543}.
CC   -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
CC       {ECO:0000256|HAMAP-Rule:MF_01543}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS39697.1}.
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DR   EMBL; ASSW01000084; EOS39697.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9K8A0; -.
DR   STRING; 1235793.C809_04616; -.
DR   PATRIC; fig|1235793.3.peg.4825; -.
DR   eggNOG; COG2759; Bacteria.
DR   HOGENOM; CLU_003601_3_3_9; -.
DR   OrthoDB; 9761733at2; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000014081; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00477; FTHFS; 1.
DR   Gene3D; 3.30.1510.10; Domain 2, N(10)-formyltetrahydrofolate synthetase; 1.
DR   Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01268; FTHFS; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01543};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_01543, ECO:0000313|EMBL:EOS39697.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01543};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563, ECO:0000256|HAMAP-
KW   Rule:MF_01543}; Reference proteome {ECO:0000313|Proteomes:UP000014081}.
FT   BINDING         65..72
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01543"
SQ   SEQUENCE   556 AA;  59529 MW;  09B370EAA93F6CFA CRC64;
     MKSDIQIAQS AKLLPITQVA AALDIDADDL ELYGKYKAKI SDEYLERIAD RKNGKLILVT
     AINPTPAGEG KTTTSVGLGQ ALGRLGKKAV IALREPSLGP CFGIKGGAAG GGMAQIVPME
     DLNLHFTGDF HAITAANNLC AALLDNHIQQ GNALGIDTRQ IVWKRCLDMN DRVLRNVVVG
     MGNKMDGFVR EDHFVITVAS EIMAVLCLAE DMKDLKKRLD RMIVAYDYEG NPVTAGQIKA
     TGAMAALLKD ALKPNLVQTL EHTPAIVHGG PFANIAHGCN SVRATKAALK MADYVVTEAG
     FGADLGAEKF FDIKCRQAGL SPDAVVLVAT IRALKYNGGV SKDSLNIENL TALERGIVNL
     EKHIENLHKY GVPVVVTLNA FVSDTQAEIG FVEKFCHDRN CDFAISEVWE KGGEGGTSLA
     NAVLNTLETK QSRFAPIYGS QLSIVEKIIR VCKEIYGAQG ASFAPAAVKQ IERLEKLGFG
     NLPVCMAKNQ YSLSDDPALL GRPKGFTINI REVYVSAGAG FVVVLTGAVM TMPGLPKEPA
     AYQIDVTDEG VITGLF
//
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