ID R9KA53_9FIRM Unreviewed; 1561 AA.
AC R9KA53;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN ORFNames=C809_04046 {ECO:0000313|EMBL:EOS43151.1};
OS Lachnospiraceae bacterium MD335.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1235793 {ECO:0000313|EMBL:EOS43151.1, ECO:0000313|Proteomes:UP000014081};
RN [1] {ECO:0000313|EMBL:EOS43151.1, ECO:0000313|Proteomes:UP000014081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COE1 {ECO:0000313|EMBL:EOS43151.1,
RC ECO:0000313|Proteomes:UP000014081};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium COE1.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS43151.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ASSW01000067; EOS43151.1; -; Genomic_DNA.
DR STRING; 1235793.C809_04046; -.
DR PATRIC; fig|1235793.3.peg.4216; -.
DR eggNOG; COG2304; Bacteria.
DR eggNOG; COG5426; Bacteria.
DR HOGENOM; CLU_246578_0_0_9; -.
DR OrthoDB; 9781333at2; -.
DR Proteomes; UP000014081; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR024163; Aerotolerance_reg_N.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR010768; GATase1-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR37947; BLL2462 PROTEIN; 1.
DR PANTHER; PTHR37947:SF2; VWFA DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07584; BatA; 1.
DR Pfam; PF07090; GATase1_like; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF13519; VWA_2; 2.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014081};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1034..1206
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1491..1561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1514..1561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1561 AA; 169144 MW; 287BD01D74801F22 CRC64;
MFEKIVQTGI CTLLQIPCES VVAFGKNPSP KAIVNGFLPA AVSIAELLQF ESLMPLAFLA
AVPIIILLYL LKPKGVDYRI SSNLLWKKLL KNEQSRTFFE KFVHNILMYL QILIIILLVI
ALMSPFIRVD NRGGGRKILL VDTSASMQHV GHYGDSRGKS RLTEAIELMC DAVQTAQDTQ
FCVVTADAVG VKLLAVDMTD TESLIQTLKS LECSDGGGNL AQAQGILDTL VGDTAENAAD
LLVFTDGSGA AAFEELRGAE KELYVVGDAA SNVANEYTVY TEREDGTYDV IVSVANYSDA
EASFDVGLYD GEDALIALKQ MRLAPSENAS CLFEAADWRG KTLTSRLDNI SFDGAAGDSL
AADNVSRAVK SRQNKIRGLL VGNGNTFLEK AYVAVTGDTI TKSQTDGAAD GVQDTGISKR
TPLKEMGYNV VIYDAGQTPQ NSEGNRLIFG DGGAKPVETL ENVVLDMTDC DLTAGLSGFT
VGVNKAYCFA LPEGAQSFLT YDGKCVGYYG ERDGHKEVVV GFDIRESDFP LRAEFPIFLA
NAMIYLSDTS WLATNVYYAG EEIALQPWAE LDRTQFESRP AKAGLYSLGN EEYRESYVVR
FQTATESDGR VTAESVGGSG EARLQKVKQT LRNVFLLLAL LLLVVEWIVY VRQMCYRGKF
YLVVRGAVLL CVLLALLGIT LKKGSSQTAT VFVVDLSNSN AEHLERMEQY LQETVGKMPS
GNVYGIVTFG KDTLVEQFLT DGTHYGGLMT LPEKAATNFE DAVSKALTLL SGDYRKRLVV
LTDGKETRGD IQNMAQALTA SQAEFLTLLY ENEETPDAYI DNVMLPSYLH PNDKYSITVL
VESNYDTDAV IALYNGSSQT AANSVHLNKG SNRFAFSAQV DTGTQSGAME NLRVQVQAQG
DTCAENDTFS AYSVVEAVPK ILVISGRDTS VSGFASVLGA AGCDYSVVSA LNAPDSINAM
LDYKSIILVD TYIDDLPTGF LENLETYVKD YGCGFICCGG EDSFALGGYR DTALETVLPV
DMQLRSVNEV PSMAMVMVID HSGSMSGALD GSGITNLDIA IRAATVAADN LRDTDYVGVL
TFDDKYTWQV ELQTAEDKTA VKDAIKQIKE GGGTTIKPAL LEACKALEDC DASVKHVVLL
TDGMGETGNY TDVISDYTAN GITLSTVAVG TGSDTKLLKR LADNCGGRYY YSDISSDIPK
IFAQEVFLGG DSYIQNGDFP LAVRGGHELT HGLFADGWPS LYGYVAATPK TASNPVIVSA
DKEDPILTVW QYGLGRTAAW NSDVTGEWSG AFSGKDDYVQ LWKRIVDYST GNADMGEDSV
NVVTAGEQTE VVYQTGDYGS GTEILVTMIA PDGESSEAKL HATAPGKYTA QLPTSQTGLY
HFNIRRTEGG EIQSYMTTAA AVQFSDEYKF DVSAAPYLRF AEQYGKVITE QENVWTRITA
GAKERYPLTN WLTAFAICLF LADVAMRRFQ YVPKFGGVTG KWKKNAAAGA DAGASGEMKQ
AQPAVQPGQL EQSAETETKK ESDPAPQKVK KQKREKKAKQ SEQVLDTSQL LKKKDERNGE
G
//
