ID R9KID3_9FIRM Unreviewed; 746 AA.
AC R9KID3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=C810_02166 {ECO:0000313|EMBL:EOS46068.1};
OS Lachnospiraceae bacterium A2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=397290 {ECO:0000313|EMBL:EOS46068.1, ECO:0000313|Proteomes:UP000014150};
RN [1] {ECO:0000313|EMBL:EOS46068.1, ECO:0000313|Proteomes:UP000014150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A2 {ECO:0000313|EMBL:EOS46068.1,
RC ECO:0000313|Proteomes:UP000014150};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium A2.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS46068.1}.
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DR EMBL; ASSX01000009; EOS46068.1; -; Genomic_DNA.
DR AlphaFoldDB; R9KID3; -.
DR STRING; 397290.C810_02166; -.
DR PATRIC; fig|397290.3.peg.2382; -.
DR eggNOG; COG0188; Bacteria.
DR HOGENOM; CLU_002977_6_1_9; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000014150; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000014150};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 10..485
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
SQ SEQUENCE 746 AA; 83473 MW; 5F852A2F06FD74FF CRC64;
MQEKEQIIRT EYSEIMQKSY IDYAMSVIIT RALPDVRDGL KPVQRRTLYD MHELGIRYDR
PYRKCARIVG DTMGKYHPHG DSSIYEALVV MAQEFKKGLP LVDGHGNFGS IEGDGAAAMR
YTEARLQKIT QEAYLADLDK NVVDFVPNFD ETEQEPSVLP VKVPNLLING AEGIAVGMAT
SIPPHNFSEV IDGVKAYMKN PDITTEELMG YIKGPDFPTG GIVVNQSDLK SIYETGAGKI
KIRGKVETEQ GKGGRQRLVI TEIPYTMVGA NIGKFLMDVY HLVETRKTSD IVDISNQSSK
EGIRIVLDLK KGADPENLCN MLYKKTRLED TFGVNMLAVA GGRPETMGLV PIIRHHVDFQ
YELATRKYQT LLAKELEKKE VQEGLIKACD VIDLIIEILR GSKNIRDAKD CLMHGNTEKI
KFRYKGSEAD AKQLCFTERQ ATAILEMRLY KLIGLEIEAL LKEHNTTLSN IAKYEEILGS
RSAMAKTIIK ELDRFQKEYG TPRKTAIENA AEAVYEEKKI EEMPVVLLMD RFGYVKSIDV
PTYERNKEAA DGENKFVIHC MNTDKLCIFT DKGQLHTVKA IDLPHGKFRD KGTPLDNISN
YNSNEEAMLC VSSLGNLLGK KLLFASSSGM LKQVKGEEFD VSKRTVAATK LNGGETLLLV
QPLAGTEEES IVMQTEKNMF LRFPASDVPE KKKSAIGVRG MKIDGKDSLL AVFLLGAAEH
TIKVKEKEIA LHRLRLANRD GKGVKK
//
