ID R9L7C4_9FIRM Unreviewed; 1022 AA.
AC R9L7C4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00013303};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=C809_01104 {ECO:0000313|EMBL:EOS51647.1};
OS Lachnospiraceae bacterium MD335.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1235793 {ECO:0000313|EMBL:EOS51647.1, ECO:0000313|Proteomes:UP000014081};
RN [1] {ECO:0000313|EMBL:EOS51647.1, ECO:0000313|Proteomes:UP000014081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COE1 {ECO:0000313|EMBL:EOS51647.1,
RC ECO:0000313|Proteomes:UP000014081};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium COE1.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS51647.1}.
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DR EMBL; ASSW01000016; EOS51647.1; -; Genomic_DNA.
DR AlphaFoldDB; R9L7C4; -.
DR STRING; 1235793.C809_01104; -.
DR PATRIC; fig|1235793.3.peg.1138; -.
DR eggNOG; COG3250; Bacteria.
DR HOGENOM; CLU_002346_0_2_9; -.
DR OrthoDB; 9762066at2; -.
DR Proteomes; UP000014081; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000014081}.
FT DOMAIN 733..1020
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1022 AA; 116359 MW; 81690A028D3C8A62 CRC64;
MAMFDYGKVK DPTFFKENVL AAHSAHMTYA GKGELSGKGS SLVTLLDGVW KFAYAPNYHS
AIKGFEAPEY DCTDWADIRV PAHIQMEGYD IPQYANTQYP WDGREEIKPG EIPERFNPVA
SYVKYFTIPP QMKGMDIHIN FRGVESGMAV WLNGAYVGYS EDSFTPSEFD LTPYLKDGEN
KLAVQVFKWT SSSWCEDQDF FRFSGIYRSV ELCAIPKTHL EDLFVKTIFE GDDFSRAVLR
AELKVKGAGS LKVSLKDQGQ VVFERTVDAA AKVLFEETVN APKLWSAEEP FLYEMEIEVL
DGAGQVTEFI PQAVGFRKFE MKKNRMLING KRIVFKGANR HEFSSVSGRH VSYAELEKDI
VTMKRNNINA IRTCHYSDDV DVYDLCDRYG LYMIAENNME THGTWDAYLR GRKDEDFILP
NGRLEWKAMM LDRINSCFQR DKNHPAIVIW SVGNESYGGE TIYGMSNLFR ELDDTRLVHY
EGVFNDRRYN DSSDMESRMY AKAAEIEAYL KDENAKPFIS CEYAHTMGNS FGAVHKYTEL
ADKENSGYQG GFIWDYIDQS IYKKDRYGKW FQAYGGDFGE RPTDYNFSGN GIAYGGERDE
SPKMQEVKYL YQNIAVTVGK EDFEVWNKNL FVSTAEFDCV AELARDGVLI GKKALTDIDV
APESRKRFPN PFEAPVLSGE YVLTVSFRLK EDTLWANRGH EVAFGQAVIA VVAEEAKQTD
KPFTVIYGNH NIGVRGAEFD VLFTELNGGL ASYRYAGKEL IEEIPKPNFW RAPTDNDMGN
DMCVRQGQWK LASMYATHKG AGIAKQDRLG NAAYENPVVH EEKDFVSVRY FYSLPTSPVS
ECQLEYRVFG DGRIQTILSY EPATGLPDMP EFGVIFKFNA DYDRVEWYGN GPAETYEDRK
MGAKLGIYQN MVSDNMAAYL VPQECGNKTD VRWAKITDRK GRGILFEADD AAINFSALPY
TPHEIENAKH PYELPEVHYT VVRVAKRQMG VGGDDSWGAP VHEEYHIAVD RKLEFRFCFR
GI
//
