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Database: UniProt
Entry: R9LNR8_9FIRM
LinkDB: R9LNR8_9FIRM
Original site: R9LNR8_9FIRM 
ID   R9LNR8_9FIRM            Unreviewed;       343 AA.
AC   R9LNR8;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   08-MAY-2019, entry version 24.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=C815_01613 {ECO:0000313|EMBL:EOS60233.1};
OS   Firmicutes bacterium M10-2.
OC   Bacteria; Firmicutes.
OX   NCBI_TaxID=1235796 {ECO:0000313|EMBL:EOS60233.1, ECO:0000313|Proteomes:UP000014154};
RN   [1] {ECO:0000313|EMBL:EOS60233.1, ECO:0000313|Proteomes:UP000014154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M10-2 {ECO:0000313|EMBL:EOS60233.1,
RC   ECO:0000313|Proteomes:UP000014154};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C.,
RA   Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S.,
RA   Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Firmicutes bacterium M10-2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EOS60233.1}.
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DR   EMBL; ASTB01000034; EOS60233.1; -; Genomic_DNA.
DR   RefSeq; WP_016319666.1; NZ_KE159697.1.
DR   STRING; 1235796.C815_01613; -.
DR   EnsemblBacteria; EOS60233; EOS60233; C815_01613.
DR   PATRIC; fig|1235796.3.peg.1629; -.
DR   OrthoDB; 853329at2; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000014154; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000014154};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014154};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       34    335       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   343 AA;  39144 MW;  29AE6B8A85E07C49 CRC64;
     MSFTINHELP SPDVLKELIP LDERSRQVKE TRDQEIKDIF TGKSDKFILI VGPCSADNPE
     TVIEYVHRLK SIEEKIKDKI LIIPRVYTNK PRTTGDGYKG MLHQPDPNEP SDLLSGIMTI
     RRMHLRILQE TGLSAADEML YPSNRDYLND LLSYEAVGAR SVENQQHRLV ASGADNPVGM
     KNPTSGDFSV MINSVTAAQH PHNFIHRLYD VETSGNPLAH TILRGGVDKF GTAIPNYHYE
     DLMRLLNEYK KTDLKNPAVI VDCNHYNSGK KYKEQIRIAK EVLHSRNYNP ELKDLVKGLM
     IESYLEEGRQ DICEDMVPGK SITDPCLGWE DTERLIYEIY EKC
//
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