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Database: UniProt
Entry: R9LW43_9FIRM
LinkDB: R9LW43_9FIRM
Original site: R9LW43_9FIRM 
ID   R9LW43_9FIRM            Unreviewed;       571 AA.
AC   R9LW43;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=PTS system lactose-specific EIICB component {ECO:0000256|ARBA:ARBA00020834};
DE            EC=2.7.1.207 {ECO:0000256|ARBA:ARBA00012802};
DE   AltName: Full=EIICB-Lac {ECO:0000256|ARBA:ARBA00029639};
GN   ORFNames=C815_01940 {ECO:0000313|EMBL:EOS59917.1};
OS   Firmicutes bacterium M10-2.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1235796 {ECO:0000313|EMBL:EOS59917.1, ECO:0000313|Proteomes:UP000014154};
RN   [1] {ECO:0000313|EMBL:EOS59917.1, ECO:0000313|Proteomes:UP000014154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M10-2 {ECO:0000313|EMBL:EOS59917.1,
RC   ECO:0000313|Proteomes:UP000014154};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Firmicutes bacterium M10-2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=lactose(out) + N(pros)-phospho-L-histidyl-[protein] = L-
CC         histidyl-[protein] + lactose 6-phosphate(in); Xref=Rhea:RHEA:42400,
CC         Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746, ChEBI:CHEBI:17716,
CC         ChEBI:CHEBI:29979, ChEBI:CHEBI:64837, ChEBI:CHEBI:79080;
CC         EC=2.7.1.207; Evidence={ECO:0000256|ARBA:ARBA00001568};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS59917.1}.
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DR   EMBL; ASTB01000038; EOS59917.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9LW43; -.
DR   STRING; 1235796.C815_01940; -.
DR   eggNOG; COG1440; Bacteria.
DR   eggNOG; COG1455; Bacteria.
DR   HOGENOM; CLU_029688_1_0_9; -.
DR   OrthoDB; 1641940at2; -.
DR   Proteomes; UP000014154; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   InterPro; IPR036095; PTS_EIIB-like_sf.
DR   InterPro; IPR003501; PTS_EIIB_2/3.
DR   InterPro; IPR013012; PTS_EIIB_3.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR004501; PTS_EIIC_3.
DR   NCBIfam; TIGR00410; lacE; 1.
DR   PANTHER; PTHR33989; -; 1.
DR   PANTHER; PTHR33989:SF4; PTS SYSTEM N,N'-DIACETYLCHITOBIOSE-SPECIFIC EIIC COMPONENT; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   Pfam; PF02302; PTS_IIB; 1.
DR   SUPFAM; SSF52794; PTS system IIB component-like; 1.
DR   PROSITE; PS51100; PTS_EIIB_TYPE_3; 1.
DR   PROSITE; PS51105; PTS_EIIC_TYPE_3; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014154};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        156..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        307..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        481..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        521..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          4..109
FT                   /note="PTS EIIB type-3"
FT                   /evidence="ECO:0000259|PROSITE:PS51100"
FT   DOMAIN          133..541
FT                   /note="PTS EIIC type-3"
FT                   /evidence="ECO:0000259|PROSITE:PS51105"
FT   MOD_RES         11
FT                   /note="Phosphocysteine; by EIIA"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00423"
SQ   SEQUENCE   571 AA;  62549 MW;  2D40B8C5F86FAE3B CRC64;
     MNKRIHILLV CAGGNSTSIL VNDMQKKLKE EECWEIEASS YEYLPKIIGK FDYILVAPQV
     KYRKSIVEEL AHQIGDIKVL EIPTNVFASC DGSLLLNMIR KVENPNSSPE EREIHMSEKS
     KSAGLIEKIS EWMMEYIAPV ANKIGNQRYL AAVRDGLTII IPATIVGGFA ILLAVPPVPS
     SITEPTNFFF AFLLGWQSWA ATYSELLLTP YNFTIGIISL YAVCGVSYRL AERYKMNALN
     NMVSAMLVFF VISGALDIAN GTISIARLGA AYMFAAMITG LLVVEINHQF DVHNIKIKLP
     ASVPPNVAGP FNVLIALVFN VVLFSLVNTT LITFTGGGIP DLIYTIFVPL MHASGSLPSI
     LFLSFLTSLF WFFGIHGDNM MSAIITPITT TALAANAEAV AAGQPMPYIY AGAMAAVYGG
     WLVLNNAMNL DLLLFSKSSQ IRSLSKVAAV PAFFNIGEPY VFGLPTVLNV YYFIPSVICQ
     IMNITAYYLL ASINVVGRFY ITMPFTTPAP LQAFLGTGGN IPALFLAVGL LGVNMIIFFP
     FMKAYDRSLM KEEELEALRE QEAASSELET A
//
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