ID   R9MF87_9FIRM            Unreviewed;      1104 AA.
AC   R9MF87;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   SubName: Full=Type I restriction enzyme, R subunit {ECO:0000313|EMBL:EOS69321.1};
GN   ORFNames=C818_03199 {ECO:0000313|EMBL:EOS69321.1};
OS   Lachnospiraceae bacterium MD308.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235799 {ECO:0000313|EMBL:EOS69321.1, ECO:0000313|Proteomes:UP000014117};
RN   [1] {ECO:0000313|EMBL:EOS69321.1, ECO:0000313|Proteomes:UP000014117}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3-2 {ECO:0000313|EMBL:EOS69321.1,
RC   ECO:0000313|Proteomes:UP000014117};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 3-2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS69321.1}.
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DR   EMBL; ASTE01000037; EOS69321.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9MF87; -.
DR   STRING; 1235799.C818_03199; -.
DR   PATRIC; fig|1235799.3.peg.3359; -.
DR   eggNOG; COG4096; Bacteria.
DR   HOGENOM; CLU_009326_0_0_9; -.
DR   OrthoDB; 9758243at2; -.
DR   Proteomes; UP000014117; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR   CDD; cd18032; DEXHc_RE_I_III_res; 1.
DR   CDD; cd18799; SF2_C_EcoAI-like; 1.
DR   Gene3D; 3.90.1570.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR025285; DUF4145.
DR   InterPro; IPR013670; EcoEI_R_C_dom.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47396:SF1; ATP-DEPENDENT HELICASE IRC3-RELATED; 1.
DR   PANTHER; PTHR47396; TYPE I RESTRICTION ENZYME ECOKI R PROTEIN; 1.
DR   Pfam; PF13643; DUF4145; 1.
DR   Pfam; PF08463; EcoEI_R_C; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014117}.
FT   DOMAIN          353..513
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
SQ   SEQUENCE   1104 AA;  126259 MW;  4784A521A68C8070 CRC64;
     MTNFDFLKKD PQFVNFADVA IAAEKIINID IGACVINCRR AMEFAVKWMY SVDDALKLPY
     QDALYSLMNT EEFRDIVDED LFRRMDFIRL TGNSAAHVSH TGKKITRDAA KLCLENLHYF
     MDFIACCYGT TYEEVVFNAA LIDEPKGQSE PALKKEIFSE VDLKALIAEN QALREELTAR
     REEQHKTYVP KPLEHSEYDT RKLYIDAMLV DVGWIEGENW LNEVKLSGIP TKSGTGYADY
     VLYDDAHRPL AIIEAKSTCK DVVSGRQQAK VYADAIEKQC GRRPVIFLSN GFDTRIDDGQ
     YPERKVSGIW SKRDLERWFN LRSMRTSLQT VSVDRAIAGR YYQEAAIKAV CDSFGGKNRR
     KALLVMATGS GKTRTVIGLV KVLLTHMWVK NVLFLADRNS LVTQAKRSFV NLMKNELSVT
     NLCEEKENYS AACVFATYQT MMNCIDNAKN EEGKIFTCGH FDLIICDEAH RSIYNKYRDI
     FNYFDALLVG LTATPKDEVD RNTYNVFELE NGVPTYGYEL SQAVADGYLV DFLSVESSLK
     FIEEGIVYSG LSEEERAVYE DTFGQEDGRI PESINSSALN EWVFNEDTIR KALNILMTKG
     IRINYGEMIG KTIIFAKNHD HAEKIREVFE KEYPNLPGYA RVIDNYMAYA QSAIDEFSAP
     EKLPQIAISV DMLDTGIDVP EVLNLVFFKK VMSKAKFWQM IGRGTRLSPG LLDGKDKDKF
     YIFDFCRNFE FFRMNAGKPT ASMLAVQGAV FNLEFQISYK LQAQEYQVKR LRLYREELVG
     HMCGKVRELN RENFAVRQHL KYVEKYSDAN NYNGITYEDT LLVRKELAPL IDSDSDEASA
     VRFDALMYGI ELASLAGKKY GHGKSDLLKK VCAIAKVANI PEIMAQTELI GQILHSEYLD
     NAGIDEFEHI RKSLRSLMKY IPRQKLRYDT DFEDDILSVE WRESELENDD LKNYKAKAEY
     YVRQNQDHVV IAKLKNNEPL TSMDVEVLEE ILWSELGTKE EYEAEYGNKP LGEFVREIVG
     LDMNAAKEAF AEYSEEAGLD SRQMYFVNQI VEYIVHNGIL KDFSVLQEPP FTDHGSMAQI
     FTDLNVWMGI KRVIENINGN ALAA
//