ID R9MFY9_9FIRM Unreviewed; 665 AA.
AC R9MFY9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=PASTA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=C818_01954 {ECO:0000313|EMBL:EOS69994.1};
OS Lachnospiraceae bacterium MD308.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1235799 {ECO:0000313|EMBL:EOS69994.1, ECO:0000313|Proteomes:UP000014117};
RN [1] {ECO:0000313|EMBL:EOS69994.1, ECO:0000313|Proteomes:UP000014117}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3-2 {ECO:0000313|EMBL:EOS69994.1,
RC ECO:0000313|Proteomes:UP000014117};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 3-2.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS69994.1}.
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DR EMBL; ASTE01000021; EOS69994.1; -; Genomic_DNA.
DR AlphaFoldDB; R9MFY9; -.
DR STRING; 1235799.C818_01954; -.
DR PATRIC; fig|1235799.3.peg.2078; -.
DR eggNOG; COG0515; Bacteria.
DR HOGENOM; CLU_412671_0_0_9; -.
DR OrthoDB; 9788659at2; -.
DR Proteomes; UP000014117; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR CDD; cd06577; PASTA_pknB; 2.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.30.10.20; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045269; Atg1-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24348:SF22; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR Pfam; PF03793; PASTA; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00740; PASTA; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51178; PASTA; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000014117}.
FT DOMAIN 46..322
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 390..457
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 554..633
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT REGION 627..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..665
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 75
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 665 AA; 74027 MW; 44A2C6B8FE5C996C CRC64;
MKLCYHCMHQ FKDEKLHTCP NCKKSLQLQQ VSVRYLKPGT VLQKKFIVGY PLGSGGFGNT
YIGWNQLLLC KVAIKEFYPE QYSGRSPDGV TVTVPDGKLK PRFRKGLQQF LEEARSVAAL
QDIKGVVAIS NFFEENGTGY IVMEYLEGMD VKTILKKSGD KKDYEWSRQV VLTVLHTLKD
IHKRGVLHRD IAPDNIFVTN EGVIKLIDFG AARHATALAN MKSEVVLKAG YAPIEQYSRN
ADQGPYTDLY AVAALFYRMM TGQKPLPANE RIEQDSLIPP SEMGIQIPRQ AEMGMMVCLN
VIPEYRLQTA DEFMETLDGK YFTPIYEPEW ILPPAEDKSS FWVKLSKLPV AAKVAVCFGG
ICLIGGIIAG AVVIGNSSSQ SVEGPISVIE AGKFRMEDYT GKSYEEAATD LRRQGVQNIA
EPVYDFSSEA GGIITKQSIA PSEVADVESE VSFTVSGGDS RYTMPDFTGY QEKDMIQFFT
DRNFDVEVHA DPYDIDVHTV TGENESQEKK NGKIVVNWYF SKDIDAGTCY DQTVAAGNAC
GADEEVAVFV SMGGEEADFI KEVPDFSGET EDGAKKRLKE SGLKDVLDIE FEKSTVYMDG
ILAGQVNGQS IGPGEKLNLI KDKEQKLTLN IQQEKPKPKP RPKPKPKPKP KSKPKPKSRQ
DRHWN
//
