ID   R9MG75_9FIRM            Unreviewed;       677 AA.
AC   R9MG75;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=GH18 domain-containing protein {ECO:0000259|PROSITE:PS51910};
GN   ORFNames=C818_02002 {ECO:0000313|EMBL:EOS70030.1};
OS   Lachnospiraceae bacterium MD308.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235799 {ECO:0000313|EMBL:EOS70030.1, ECO:0000313|Proteomes:UP000014117};
RN   [1] {ECO:0000313|EMBL:EOS70030.1, ECO:0000313|Proteomes:UP000014117}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3-2 {ECO:0000313|EMBL:EOS70030.1,
RC   ECO:0000313|Proteomes:UP000014117};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 3-2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS70030.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ASTE01000021; EOS70030.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9MG75; -.
DR   STRING; 1235799.C818_02002; -.
DR   PATRIC; fig|1235799.3.peg.2115; -.
DR   eggNOG; COG3858; Bacteria.
DR   HOGENOM; CLU_020253_0_0_9; -.
DR   OrthoDB; 9775889at2; -.
DR   Proteomes; UP000014117; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.10.50.10; -; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR029070; Chitinase_insertion_sf.
DR   InterPro; IPR001223; Glyco_hydro18_cat.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR003646; SH3-like_bac-type.
DR   PANTHER; PTHR46066:SF2; CHITINASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR46066; CHITINASE DOMAIN-CONTAINING PROTEIN 1 FAMILY MEMBER; 1.
DR   Pfam; PF00704; Glyco_hydro_18; 1.
DR   Pfam; PF08239; SH3_3; 1.
DR   SMART; SM00636; Glyco_18; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   PROSITE; PS51910; GH18_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014117};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        102..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          345..677
FT                   /note="GH18"
FT                   /evidence="ECO:0000259|PROSITE:PS51910"
FT   REGION          1..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..89
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   677 AA;  77659 MW;  6B7E19D1AA3C9FDC CRC64;
     MEENEKISRT ESNQPTRNIS ESNGQSRVRR PSTGTGTTVR RRRPEGTRTS AERRRTERTE
     SPVNRRRTDS GEVSARSRQR RTSDGNRQAR RRQSRRRRKR NLMLKMILFV ILLIAAVVGA
     FLWKKYSPSK EKADLKEYYG IEKEGQLAIT VNNEITEPHG MISEGKAYVQ YETVRDYISN
     RFYWDSNENI LLYTLPKDIV SVEVGSKDYM VSNDKNSEDY VILKTEGSTA YIALDFIQQY
     TNIDFAVYDK PSRVSIVTEW GKKSVSQVKK NTQVRYRGGV KSPILTEIKK KDEVVVLEEE
     ENWKKVRTKD GFIGYVKNSA LKKTEKKNIT RDFEEPKYSN ISLDYTINLV WHNVTNREAN
     NNVLDKIAET KGLTTIAPTW YSVKNTDGDI TSLSSADYVE KARQLKVDVW ATVRDFDGGI
     GSQKETYELL SSTSKREKLI NQLISDALQT NIAGINVDFE KVSEECGEHF IQFIRELSVK
     CRQSALVLSV DNYVPKNYNT QYNRKEQGVF ADYVIIMGYD EHYGGSPEAG SVASYNFVQE
     GIEETIKEVP AEKVINGVPF FTRLWSEKPK TQEQLAKEQG TEEAQYANEV KSEAYGMTKA
     KEKVSEAGAE ITWDEETKQN FATWVDGDTT YKIWLEDVKS LEPRLKLMKE YKLAGTAAWA
     LGQETSDVWP LIQQYVN
//