ID   R9MSI0_9FIRM            Unreviewed;       746 AA.
AC   R9MSI0;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EOS73723.1};
GN   ORFNames=C819_03523 {ECO:0000313|EMBL:EOS73723.1};
OS   Lachnospiraceae bacterium 10-1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235800 {ECO:0000313|EMBL:EOS73723.1, ECO:0000313|Proteomes:UP000014134};
RN   [1] {ECO:0000313|EMBL:EOS73723.1, ECO:0000313|Proteomes:UP000014134}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10-1 {ECO:0000313|EMBL:EOS73723.1,
RC   ECO:0000313|Proteomes:UP000014134};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 10-01.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS73723.1}.
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DR   EMBL; ASTF01000035; EOS73723.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9MSI0; -.
DR   STRING; 1235800.C819_03523; -.
DR   eggNOG; COG1609; Bacteria.
DR   eggNOG; COG1653; Bacteria.
DR   HOGENOM; CLU_023027_0_0_9; -.
DR   OrthoDB; 9770625at2; -.
DR   Proteomes; UP000014134; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   CDD; cd06267; PBP1_LacI_sugar_binding-like; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR006059; SBP.
DR   PANTHER; PTHR30146:SF152; HTH-TYPE TRANSCRIPTIONAL REGULATOR EBGR-RELATED; 1.
DR   PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13416; SBP_bac_8; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014134};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          2..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50932"
FT   DOMAIN          3..46
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50943"
SQ   SEQUENCE   746 AA;  85565 MW;  C705ED01555B5199 CRC64;
     MPTIKDVAKK SGVSIATVSN ILNNKASVSE EIYQRVYSAM EELDYKPNML ARNLKSNGVK
     FVGIIVPAFL GIYQDIIEGI QRELSEYDFY LITRTTNDMI NKEKKLIDEF IGLGVCGIFV
     VTSFRDMEYY KKAADAGISL VFIERTVDEL NYSSVVFDNR SMVRNLLRSL LTKTCKVEEL
     WLITGDLSYS SERDFLEGAY LAVEEAGMQA KELKRSQVSF SELQAFADMM NLIGRADEIP
     PYVILSSERI LESFMEMLSI YDRKDTHIFV PVGERWSSAG RSESICEIPR RAVYCGKRCA
     QLMLEFVKKP ATNENTQIVI PTQEVKEEQL ISYIPALHRS LKILLTSNAM TTALLRLLPA
     FMRESGIQVE TKIFTYQQEL YEEIMKQYES GSSEYDVYMM DSPWIEYFRQ IQCVLTLNPY
     LEKEKEYVKS FVPEIWNKLN GGNGRIIGIP LVSMTQLLLY RRDLFKSPAL QRAYYRKNGL
     ELGLPSTWTE YNFLAKFFTR EFTKDSPTEY GTCLLGKKPN GLIQEFFPRQ WSFHGAVMNK
     NQVVIDSLQN VRAVRNLMEA YECSLPQIWD LMENEQIEAF AKGNIAFIST YSGHIKSILD
     SQFGSIGDRL GYAVLPGKYS LVGSWLLAVN GNCQNPDTAF SFIKWITSGT RAMQCSVLGG
     FMPKQTVNLS EQIKTIYPWN EHLEDYVKME RQRENIRNAR GTYINNYSIE GVIADGLQDV
     LCKKCGIEEM LEDCKEQIKA MVREWK
//