ID   R9MVB3_9FIRM            Unreviewed;       611 AA.
AC   R9MVB3;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=BlaR1 family beta-lactam sensor/signal transducer {ECO:0008006|Google:ProtNLM};
GN   ORFNames=C818_00531 {ECO:0000313|EMBL:EOS71727.1};
OS   Lachnospiraceae bacterium MD308.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235799 {ECO:0000313|EMBL:EOS71727.1, ECO:0000313|Proteomes:UP000014117};
RN   [1] {ECO:0000313|EMBL:EOS71727.1, ECO:0000313|Proteomes:UP000014117}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3-2 {ECO:0000313|EMBL:EOS71727.1,
RC   ECO:0000313|Proteomes:UP000014117};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 3-2.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M56 family.
CC       {ECO:0000256|ARBA:ARBA00011075}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS71727.1}.
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DR   EMBL; ASTE01000005; EOS71727.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9MVB3; -.
DR   STRING; 1235799.C818_00531; -.
DR   PATRIC; fig|1235799.3.peg.568; -.
DR   eggNOG; COG2602; Bacteria.
DR   eggNOG; COG4219; Bacteria.
DR   HOGENOM; CLU_035412_0_2_9; -.
DR   Proteomes; UP000014117; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   CDD; cd07341; M56_BlaR1_MecR1_like; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   InterPro; IPR008756; Peptidase_M56.
DR   PANTHER; PTHR34978; POSSIBLE SENSOR-TRANSDUCER PROTEIN BLAR; 1.
DR   PANTHER; PTHR34978:SF3; SLR0241 PROTEIN; 1.
DR   Pfam; PF05569; Peptidase_M56; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014117};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        37..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        112..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          13..309
FT                   /note="Peptidase M56"
FT                   /evidence="ECO:0000259|Pfam:PF05569"
FT   DOMAIN          398..605
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   611 AA;  68781 MW;  F1AEDB8296A9F47A CRC64;
     MHTFIIRFTL DCILLSLFVI IPAALKRLLR SRLSGQMQYN LWVLLLPVLF VPFLPGHPAK
     TLLSFLTQKL ALTKRGSAPA ASLSSQTSAT QTSETFGRIK DFAMPVNVRE SVFPLLLFLI
     WTIGMAVTAA FLFFSLIRLG RLKKSARILE DGQIFWLLHN CLDNLGIKRR IPIYLAPGLK
     SPVITGLFCP AIFIPAGLCH TYTPQEIRHM LLHELQHYRR KDAWINHLAN IVRILYWFHP
     AVRYWLKELR LAQEIACDTA VLALLGTDGC KDYGCTLIRF AKERSLSPSP LWNSIGGNMR
     QMRERILNIA EFHPLSRPQK FFQYTVLLLT AAFLFFLSPV LSAGEEIRNI AADFSGSDTY
     RFDHSGKDIT YSDLSSCFGT YEGSFVLYNA SDNTWTIYNE EAARIRTAPA STYKIYDALL
     GLDEGIITPA DSLLSWDKTA YPFPEWEADQ NLDSAMKNSV NWYFQRIDAQ AGNSRIRTFL
     KSIAYGNQTA GSNKTEDRPA QYWIDGTLKI SPLEQVILLE RLFNGKLPAA PSSVDAVKEA
     LCLQKDESGS LYGKTGTVKM NSQEVSGWFV GYTEIEQTPY FFATNIQGQT GAAGSRAYEI
     TRAVLDTLLT D
//