ID   R9MZL8_9FIRM            Unreviewed;       642 AA.
AC   R9MZL8;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=DNA polymerase bacteriophage-type {ECO:0000313|EMBL:EOS73262.1};
GN   ORFNames=C819_03987 {ECO:0000313|EMBL:EOS73262.1};
OS   Lachnospiraceae bacterium 10-1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1235800 {ECO:0000313|EMBL:EOS73262.1, ECO:0000313|Proteomes:UP000014134};
RN   [1] {ECO:0000313|EMBL:EOS73262.1, ECO:0000313|Proteomes:UP000014134}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10-1 {ECO:0000313|EMBL:EOS73262.1,
RC   ECO:0000313|Proteomes:UP000014134};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 10-01.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS73262.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ASTF01000040; EOS73262.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9MZL8; -.
DR   STRING; 1235800.C819_03987; -.
DR   PATRIC; fig|1235800.3.peg.4227; -.
DR   eggNOG; COG0749; Bacteria.
DR   HOGENOM; CLU_012044_0_0_9; -.
DR   Proteomes; UP000014134; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   CDD; cd08642; DNA_pol_A_pol_I_A; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014134}.
FT   DOMAIN          366..608
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   642 AA;  72322 MW;  5409686A6DAA567B CRC64;
     MKSIEIDIET YSDVDLSKCG VYRYSSSPNF EILLFGYSVD GGEVRVVDLC QGENIPVEIL
     AAISDESVTK WAFNAMFERV CLSNYLGEWL EPESWKCSMV WSATLGLPLS LENVGAVLGL
     EKQKLSEGKD LIRYFCVPCK PTKANGGRTR NLPEHDREKW GRFKAYNLRD VEAEMQIQQR
     LSKFPVPDFV WEEYWQDQEI NDRGIGVDME MVAQAIAMDG RSKSELSAAM QKLTELENPN
     SVQQMKQWLS ENGMETDSLD KKAVAELLKT APEPLGEALA LRQQLAKSSV KKYQAMENAV
     CADRRAHGMF QFYGANRTGR YSGRIIQLQN LPQNHIPDLA QARELVKAGD YDALAMLYED
     IPDTLSQLIR TAFVPQDGRK FIVADFSAIE ARVLAWIAGE RWRIKVFEGG GDIYCASASQ
     MFHVPVEKHG VNGHLRQKGK IAELALGYGG SVGALKSMGA LEMGIAEEEL QPLVSAWRDS
     NPSITEFWWA ADRAVKECIK KRVPTETHGI RFDYQSGMLF ITLFSGRRLA YVKPRIGENR
     FGGESVTYMG VSGTKKWERL ESYGPKFVEN IVQAVSRDIL CYAMRTLRNC AIVATVHDEI
     IIEADRRMSL SAVCEQMGRT PPWAKGLLLR ADGYECDFYQ KD
//