ID R9N0Z9_9FIRM Unreviewed; 356 AA.
AC R9N0Z9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Nudix hydrolase domain-containing protein {ECO:0000259|PROSITE:PS51462};
GN ORFNames=C819_01015 {ECO:0000313|EMBL:EOS76989.1};
OS Lachnospiraceae bacterium 10-1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1235800 {ECO:0000313|EMBL:EOS76989.1, ECO:0000313|Proteomes:UP000014134};
RN [1] {ECO:0000313|EMBL:EOS76989.1, ECO:0000313|Proteomes:UP000014134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10-1 {ECO:0000313|EMBL:EOS76989.1,
RC ECO:0000313|Proteomes:UP000014134};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 10-01.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS76989.1}.
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DR EMBL; ASTF01000010; EOS76989.1; -; Genomic_DNA.
DR AlphaFoldDB; R9N0Z9; -.
DR STRING; 1235800.C819_01015; -.
DR PATRIC; fig|1235800.3.peg.1093; -.
DR eggNOG; COG0494; Bacteria.
DR eggNOG; COG1443; Bacteria.
DR HOGENOM; CLU_818576_0_0_9; -.
DR OrthoDB; 9804563at2; -.
DR Proteomes; UP000014134; Unassembled WGS sequence.
DR GO; GO:0008413; F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd03427; MTH1; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 2.
DR InterPro; IPR003562; Mutator_MutX_prot.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR43758; 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE; 1.
DR PANTHER; PTHR43758:SF2; OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE; 1.
DR Pfam; PF00293; NUDIX; 2.
DR PRINTS; PR01402; MUTATORMUTX.
DR SUPFAM; SSF55811; Nudix; 2.
DR PROSITE; PS51462; NUDIX; 2.
DR PROSITE; PS00893; NUDIX_BOX; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000014134}.
FT DOMAIN 2..130
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT DOMAIN 184..331
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 356 AA; 40947 MW; D5D7EA39B745114E CRC64;
MKSQLTTLCY IEKGEKYLML HRVSKKNDIN KDKWIGVGGH FEGEESPEEC LLREVYEETG
LTLTSYQFRG IVTFCSEGYL VEYMCLYTAD GFEGELKECE EGNLEWVEKD KMEELNLWDG
DILFLDLLNR NVPFFSLKLC YRKNGSWHRA LLDGRELELF DLVREDGSPT GHVMERCMVH
KRGELHRTVH IWVVNKKADG SVEVLLQKRS QAKDAYPGCY DVSAAGHMLA GEEFEAAASR
ELFEELGIDA QEGELRFIGY HEGYVEAAFW GQPFKDWEIS AVYLYEKPVK PENLVIQKSE
VEEVSFWDYD KVFAGILEGT LKTCIYPEEF KLIKKALEPG FSAQGVRVAD CPRTKT
//
