ID R9NJK3_9FIRM Unreviewed; 351 AA.
AC R9NJK3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC domain-containing protein {ECO:0000259|Pfam:PF02570};
GN ORFNames=C817_02040 {ECO:0000313|EMBL:EOS80167.1};
OS Dorea sp. 5-2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX NCBI_TaxID=1235798 {ECO:0000313|EMBL:EOS80167.1, ECO:0000313|Proteomes:UP000014211};
RN [1] {ECO:0000313|EMBL:EOS80167.1, ECO:0000313|Proteomes:UP000014211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5-2 {ECO:0000313|EMBL:EOS80167.1,
RC ECO:0000313|Proteomes:UP000014211};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Dorea bacterium 5-2.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the CobH/CbiC family.
CC {ECO:0000256|ARBA:ARBA00009774}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS80167.1}.
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DR EMBL; ASTD01000037; EOS80167.1; -; Genomic_DNA.
DR AlphaFoldDB; R9NJK3; -.
DR STRING; 1235798.C817_02040; -.
DR PATRIC; fig|1235798.3.peg.2156; -.
DR eggNOG; COG2082; Bacteria.
DR eggNOG; COG2087; Bacteria.
DR HOGENOM; CLU_789244_0_0_9; -.
DR OrthoDB; 9780708at2; -.
DR UniPathway; UPA00148; UER00236.
DR Proteomes; UP000014211; Unassembled WGS sequence.
DR GO; GO:0043752; F:adenosylcobinamide kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0008820; F:cobinamide phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016993; F:precorrin-8X methylmutase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.10230; Cobalamin biosynthesis CobH/CbiC, precorrin-8X methylmutase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003722; Cbl_synth_CobH/CbiC.
DR InterPro; IPR036588; CobH/CbiC_sf.
DR InterPro; IPR003203; CobU/CobP.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43588; COBALT-PRECORRIN-8 METHYLMUTASE; 1.
DR PANTHER; PTHR43588:SF1; COBALT-PRECORRIN-8 METHYLMUTASE; 1.
DR Pfam; PF02570; CbiC; 1.
DR Pfam; PF02283; CobU; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF63965; Precorrin-8X methylmutase CbiC/CobH; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000014211}.
FT DOMAIN 153..349
FT /note="Cobalamin biosynthesis precorrin-8X methylmutase
FT CobH/CbiC"
FT /evidence="ECO:0000259|Pfam:PF02570"
SQ SEQUENCE 351 AA; 39028 MW; 06C22D26922CA277 CRC64;
MKMIIGGSFQ GKTDYARRKY PGIAWADGRD CPYDAVRTCE GIYHLEAYIR RAMQEKEGRQ
YLDLLCGLSK INPGIVVISD EIGYGLVPAD PFERRYRETA GRICTRLAAD AEQVDRIVCG
IGTAIKTRRR DMCEEAAPEV LKEVRCDRIP PEEIEKKSFE IITEELKDTP LVPGTEAIVK
RCIHTSADFE YAKNLVFSEN AVEKIQEAVK NGASIVTDTQ MGKAGINKNR LKKYGGQVYC
FMSDEDVAIE AKRRGLTRAA VSMEKAAKLD AKLIFAVGNA PTALIRLYEL IREGRLLPEA
VIAVPVGFVN VVQSKELILT LKDTPYIVAR GRKGGSNIAA CICNAFLYMM E
//