ID R9NW48_PSEHS Unreviewed; 588 AA.
AC R9NW48;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 22-FEB-2023, entry version 43.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN ORFNames=PHSY_000279 {ECO:0000313|EMBL:GAC92724.1};
OS Pseudozyma hubeiensis (strain SY62) (Yeast).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Pseudozyma.
OX NCBI_TaxID=1305764 {ECO:0000313|EMBL:GAC92724.1, ECO:0000313|Proteomes:UP000014071};
RN [1] {ECO:0000313|Proteomes:UP000014071}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SY62 {ECO:0000313|Proteomes:UP000014071};
RX PubMed=23814110; DOI=10.1128/genomea.00409-13;
RA Konishi M., Hatada Y., Horiuchi J.;
RT "Draft genome sequence of the basidiomycetous yeast-like fungus Pseudozyma
RT hubeiensis SY62, which produces an abundant amount of the biosurfactant
RT mannosylerythritol lipids.";
RL Genome Announc. 1:E0040913-E0040913(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
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DR EMBL; DF238767; GAC92724.1; -; Genomic_DNA.
DR RefSeq; XP_012186311.1; XM_012330921.1.
DR AlphaFoldDB; R9NW48; -.
DR STRING; 1305764.R9NW48; -.
DR GeneID; 24105590; -.
DR eggNOG; KOG0169; Eukaryota.
DR HOGENOM; CLU_002738_3_1_1; -.
DR OrthoDB; 2900494at2759; -.
DR Proteomes; UP000014071; Unassembled WGS sequence.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd08598; PI-PLC1c_yeast; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF169; PHOSPHOINOSITIDE PHOSPHOLIPASE C; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW Reference proteome {ECO:0000313|Proteomes:UP000014071};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DOMAIN 317..434
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT DOMAIN 429..569
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 26..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 64959 MW; 6D65FBFBCE44F6C5 CRC64;
MSDNTDPNTK DGKAAPSVLT SKFAKLNPFS KTGASDPEGG GDNLGEEVEF DSIAGGGHAA
RRTKITKSEL RVSHALRQFL VDEKLISPAD AQLDDPQASS SDALKALVDQ SHIDVPEYVR
DRSRPLSEYF VSSSHNTYLL AHQLYGTSSA IAYEHVLVTG ARCVEIDAWD NDDDPQEPKV
THGYTLASHI PFRAVCETMK QAIQKEEEEA QRDQSFKVAP VLLSLENHCG HAGQQRLVEI
MHEVWGDLLI SGPVEKNEPA SEHTSVEHLG AKIAVMVEFH LSKEAPVAEA TEEDDAEEKL
NKAKRNEAKK AGIIPELCAL GVYAQSVKPV NDSWYTSTLT NGPHDHLINI SETGLIDLLP
KQATAIKKHN AQHLMRVYPK GTRISSKNLN PVPFWGVGAQ VCALNWQTFD HSVQLNEALF
SGSDGYVLKP PGLRIDGDGN TSLGRHKLTL HIAGATDLPL PAGKDADEIR PYVTCTLILP
SDLKSEPPKR KTNAYKQHKL GIIHKGEQPI PTDPLWNEQL EWDFEHDELA FLRILIKSDD
KFARNPLFAV AAVRLVYAAQ GWKFIRLLDL KGRETHSTLL VKFDLQKL
//
