ID R9R6C7_DANRE Unreviewed; 370 AA.
AC R9R6C7; A0A0N9NVU5; X1WFK4;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Teleost multiple tissue opsin 2a {ECO:0000313|EMBL:AGK24997.1, ECO:0000313|Ensembl:ENSDARP00000129008};
DE SubName: Full=Teleost multiple tissue opsin-1a {ECO:0000313|EMBL:ALG92547.1};
GN Name=tmtops2a {ECO:0000313|EMBL:AGK24997.1,
GN ECO:0000313|Ensembl:ENSDARP00000129008,
GN ECO:0000313|RefSeq:NP_001268434.1,
GN ECO:0000313|ZFIN:ZDB-GENE-130129-3};
GN Synonyms=tmt1a {ECO:0000313|EMBL:ALG92547.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ALG92547.1};
RN [1] {ECO:0000313|RefSeq:NP_001268434.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23000151;
RA Fernandes A.M., Fero K., Arrenberg A.B., Bergeron S.A., Driever W.,
RA Burgess H.A.;
RT "Deep brain photoreceptors control light-seeking behavior in zebrafish
RT larvae.";
RL Curr. Biol. 22:2042-2047(2012).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000129008, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129008};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|EMBL:AGK24997.1, ECO:0000313|RefSeq:NP_001268434.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23776409; DOI=10.1371/journal.pbio.1001585;
RA Fischer R.M., Fontinha B.M., Kirchmaier S., Steger J., Bloch S., Inoue D.,
RA Panda S., Rumpel S., Tessmar-Raible K.;
RT "Co-expression of VAL- and TMT-opsins uncovers ancient photosensory
RT interneurons and motorneurons in the vertebrate brain.";
RL PLoS Biol. 11:E1001585-E1001585(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000129008}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129008};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [5] {ECO:0000313|EMBL:ALG92547.1, ECO:0000313|RefSeq:NP_001268434.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26450929; DOI=10.1101/gr.189886.115;
RA Davies W.I., Tamai T.K., Zheng L., Fu J.K., Rihel J., Foster R.G.,
RA Whitmore D., Hankins M.W.;
RT "An extended family of novel vertebrate photopigments is widely expressed
RT and displays a diversity of function.";
RL Genome Res. 25:1666-1679(2015).
RN [6] {ECO:0000313|RefSeq:NP_001268434.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [7] {ECO:0000313|EMBL:ALG92547.1}
RP NUCLEOTIDE SEQUENCE.
RA Hoefler B.C., Straight P.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|RefSeq:NP_001268434.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004951}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000256|RuleBase:RU004951}.
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DR EMBL; CR956630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU468896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JX293361; AGK24997.1; -; mRNA.
DR EMBL; KT008407; ALG92547.1; -; mRNA.
DR RefSeq; NP_001268434.1; NM_001281505.1.
DR STRING; 7955.ENSDARP00000129008; -.
DR PaxDb; 7955-ENSDARP00000129008; -.
DR Ensembl; ENSDART00000155865; ENSDARP00000129008; ENSDARG00000061515.
DR Ensembl; ENSDART00000155865.2; ENSDARP00000129008.1; ENSDARG00000061515.7.
DR GeneID; 568691; -.
DR KEGG; dre:568691; -.
DR AGR; ZFIN:ZDB-GENE-130129-3; -.
DR CTD; 568691; -.
DR ZFIN; ZDB-GENE-130129-3; tmtops2a.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_3_0_1; -.
DR OMA; CFRQLFH; -.
DR OrthoDB; 2960637at2759; -.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000061515; Expressed in dorsal tegmental nucleus and 22 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; IBA:GO_Central.
DR GO; GO:0009881; F:photoreceptor activity; IDA:ZFIN.
DR GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR CDD; cd15086; 7tmA_tmt_opsin; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR002962; Peropsin.
DR InterPro; IPR027430; Retinal_BS.
DR PANTHER; PTHR24240:SF73; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24240; OPSIN; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR PRINTS; PR01244; PEROPSIN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 2: Evidence at transcript level;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991, ECO:0000256|RuleBase:RU004951};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU004951};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004951};
KW Photoreceptor protein {ECO:0000256|ARBA:ARBA00022543,
KW ECO:0000256|RuleBase:RU004951};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004951};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Retinal protein {ECO:0000256|ARBA:ARBA00022925,
KW ECO:0000256|RuleBase:RU004951};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004951};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU004951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004951};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004951}.
FT TRANSMEM 41..65
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004951"
FT TRANSMEM 77..101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004951"
FT TRANSMEM 113..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004951"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004951"
FT TRANSMEM 201..226
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004951"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004951"
FT TRANSMEM 279..305
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004951"
FT DOMAIN 56..303
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 348..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 41007 MW; CFDF8973614B11F6 CRC64;
MFPEETNMSY ISNGTDDDLL SALEDWSDTP AEKLSRTGHN VVAVILGSIL IFGTLNNLVV
LVLFCKFKTL RTPVNMLLLN ISVSDMLVCL FGTTLSFAAS IRGRWLVGRH GCMWYGFVNS
CFGIVSLISL AILSYDRYST LTVYNKRAPD YSKPLLAVGG SWLYSLFWTV PPLLGWSSYG
LEGAGTSCSV TWTANTPQSH SYIICLFIFC LGIPVLVMVY CYSRLICAVK QVGRIRKTAA
RRREYHILFM VITTVVCYLL CWMPYGVVAM MATFGRPGII SPIASVVPSL LAKSSTVINP
LIYILMNKQF YRCFLILIHC KHSSLENGQS SMPSRTTGIQ LNRRPYSNPV ADNAPPSIDL
QNDCSTPVSG
//
