ID R9T4R7_METII Unreviewed; 459 AA.
AC R9T4R7;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN ORFNames=MMINT_03050 {ECO:0000313|EMBL:AGN25700.1};
OS Methanomassiliicoccus intestinalis (strain Issoire-Mx1).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata;
OC Methanomassiliicoccales; Methanomassiliicoccaceae; Methanomassiliicoccus.
OX NCBI_TaxID=1295009 {ECO:0000313|EMBL:AGN25700.1, ECO:0000313|Proteomes:UP000014070};
RN [1] {ECO:0000313|EMBL:AGN25700.1, ECO:0000313|Proteomes:UP000014070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Issoire-Mx1 {ECO:0000313|EMBL:AGN25700.1,
RC ECO:0000313|Proteomes:UP000014070};
RX PubMed=23846268; DOI=10.1128/genomeA.00453-13;
RA Borrel G., Harris H.M., Parisot N., Gaci N., Tottey W., Mihajlovski A.,
RA Deane J., Gribaldo S., Bardot O., Peyretaillade E., Peyret P.,
RA O'Toole P.W., Brugere J.F.;
RT "Genome sequence of 'Candidatus Methanomassiliicoccus intestinalis'
RT Issoire-Mx1, a third thermoplasmatales-related methanogenic archaeon from
RT human feces.";
RL Genome Announc. 1:142-142(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP005934; AGN25700.1; -; Genomic_DNA.
DR RefSeq; WP_020448225.1; NC_021353.1.
DR AlphaFoldDB; R9T4R7; -.
DR STRING; 1295009.MMINT_03050; -.
DR GeneID; 41322741; -.
DR KEGG; mer:MMINT_03050; -.
DR HOGENOM; CLU_012893_5_0_2; -.
DR InParanoid; R9T4R7; -.
DR OrthoDB; 214119at2157; -.
DR Proteomes; UP000014070; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd13138; MATE_yoeA_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014070};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 18..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 459 AA; 49700 MW; 7D1F9C084C6124C4 CRC64;
MTANGHVRNL TEGRPLKLIL IFALPMIIGG VVQQLYSVVD TLIVGNTLGS HALAAVGATG
STIFFMISFM LGLTNAFSIV TAHHFGADNH AMVKKTVVNA IFLSAICAVI LSLVGIYGAR
PLMELLQTPP DIINESVIYI QICIGFSVAQ LAYDVAAAIL RAIGDSKTPL YFLMISAVSN
IILDLVFILG MDMGVAGAAI ATVISQAISA VLCIAYIIKK YPIFHISRHE FRPDFRQLKL
VTKMGITMGL QSCFIAVGEM AATGVINGFG TTVVAAYTTG VRVEEFATLA FINLSQAFSI
YAGQNIGAHK TERIQEGFKK IAMLVIFLSF VSTALIFIFG DDVARWFISD ADSQIESVVS
IAYQYLCTSA CFYSFLGMIL LYNNTLRGMG ELGIPLMSGI IELLSKVGLS IILASIFGYS
GIWYAAPIGW MLGMLPSMIR YHQGNWKKRP DKIADAYPE
//
