ID RABX_DICDI Reviewed; 444 AA.
AC Q553R6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Ras-related protein RabX;
DE Flags: Precursor;
GN Name=rabX; ORFNames=DDB_G0275327;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69729.1; -; Genomic_DNA.
DR RefSeq; XP_643654.1; XM_638562.1.
DR AlphaFoldDB; Q553R6; -.
DR SMR; Q553R6; -.
DR STRING; 44689.Q553R6; -.
DR PaxDb; 44689-DDB0230046; -.
DR EnsemblProtists; EAL69729; EAL69729; DDB_G0275327.
DR GeneID; 8619920; -.
DR KEGG; ddi:DDB_G0275327; -.
DR dictyBase; DDB_G0275327; rabX.
DR eggNOG; KOG0084; Eukaryota.
DR HOGENOM; CLU_617411_0_0_1; -.
DR InParanoid; Q553R6; -.
DR Reactome; R-DDI-210500; Glutamate Neurotransmitter Release Cycle.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8873719; RAB geranylgeranylation.
DR Reactome; R-DDI-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:Q553R6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0017157; P:regulation of exocytosis; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR47980; LD44762P; 1.
DR PANTHER; PTHR47980:SF24; LD44762P; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00175; RAB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
PE 3: Inferred from homology;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Palmitate; Prenylation; Reference proteome.
FT CHAIN 1..441
FT /note="Ras-related protein RabX"
FT /id="PRO_0000332773"
FT PROPEP 442..444
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000370838"
FT REGION 91..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 51..58
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 29..36
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 73..77
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 207..210
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 441
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 439
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 441
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 444 AA; 50736 MW; 4923D768B99BE7CA CRC64;
MSKTNQNLTI DKVIDNNNNI YLLKLLMIGG DVCSKNGISM VEKFLKHDKN LIQVFDDYDS
TDEYINFKMK LNEFSSIDTS NSINNGIIYS ENNKNKNNNN NYNYNNNNYN NNNNNNNNNN
NNNNNNNNNN NNNNNSNFKI QIQIKDLSDC YCDLKIQTIP SCFYRGIHGF IIVYDINDHI
AYNNIPKWIE EINSFSMKNS KIIVVCNDSN SKTPNFSDSS SSSSSSSSSN IIPLNKNTKN
KVVGGVGVDP ILANKLFQSL SIPHFIVSVD TNENIKMAFN SLKTLIFENN PLFQFFKLQG
DDNNNNNNNN NNNNNNNNNN NNNNNNNNNN LNYLNNLNNL NNLNNENNIN NNSLNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNTYNND LKTNKKSLEI KKHNSNIEKK
EVKQNIKDKK NKNKNKNACT CNLM
//
