ID RATA_VIBCH Reviewed; 144 AA.
AC P0C6Q0; P52122; Q9KTQ2;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Ribosome association toxin RatA;
GN Name=ratA; OrderedLocusNames=VC_0849;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC Binds to 50S ribosomal subunits, preventing them from associating with
CC 30S subunits to form 70S ribosomes. Its antitoxin is unknown (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ribosome association toxin RatA family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF94011.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE003852; AAF94011.1; ALT_INIT; Genomic_DNA.
DR PIR; D82272; D82272.
DR RefSeq; NP_230496.1; NC_002505.1.
DR RefSeq; WP_000815876.1; NZ_LT906614.1.
DR AlphaFoldDB; P0C6Q0; -.
DR SMR; P0C6Q0; -.
DR STRING; 243277.VC_0849; -.
DR DNASU; 2614516; -.
DR EnsemblBacteria; AAF94011; AAF94011; VC_0849.
DR KEGG; vch:VC_0849; -.
DR PATRIC; fig|243277.26.peg.809; -.
DR eggNOG; COG2867; Bacteria.
DR HOGENOM; CLU_079653_3_1_6; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0048039; F:ubiquinone binding; IEA:InterPro.
DR GO; GO:0045333; P:cellular respiration; IEA:InterPro.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:InterPro.
DR CDD; cd07813; COQ10p_like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR044996; COQ10-like.
DR InterPro; IPR005031; COQ10_START.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR12901:SF10; COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12901; SPERM PROTEIN HOMOLOG; 1.
DR Pfam; PF03364; Polyketide_cyc; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
PE 3: Inferred from homology;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..144
FT /note="Ribosome association toxin RatA"
FT /id="PRO_0000192478"
SQ SEQUENCE 144 AA; 15875 MW; 5BE8D3774743A7DA CRC64;
MKQVSRSALV SFSAEQMFHL VNDVARYPEF LPGCSGSCVL EQSEAHMVAS VDVSKAGISK
TFTTSNQLTP GVSIAMSLVD GPFKTLRGGW FFTPLDEAAC KVELRLEFEF SSKMIELAFG
KIFNELTSNM VNAFTRRAKQ VYGE
//
