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Database: UniProt
Entry: RCR1_YEAST
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ID   RCR1_YEAST              Reviewed;         213 AA.
AC   P38212; D6VQ06;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   08-NOV-2023, entry version 141.
DE   RecName: Full=Protein RCR1;
DE   AltName: Full=Resistance to Congo red protein 1;
GN   Name=RCR1; OrderedLocusNames=YBR005W; ORFNames=YBR0111;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TOPOLOGY.
RX   PubMed=15590673; DOI=10.1074/jbc.m409428200;
RA   Imai K., Noda Y., Adachi H., Yoda K.;
RT   "A novel endoplasmic reticulum membrane protein Rcr1 regulates chitin
RT   deposition in the cell wall of Saccharomyces cerevisiae.";
RL   J. Biol. Chem. 280:8275-8284(2005).
RN   [5]
RP   INTERACTION WITH PMT4 AND RSP5, AND MUTAGENESIS OF 82-PRO-PRO-83; PRO-105;
RP   LYS-130 AND LYS-208.
RX   PubMed=17213653; DOI=10.1271/bbb.60446;
RA   Imai K., Noda Y., Adachi H., Yoda K.;
RT   "Peculiar protein-protein interactions of the novel endoplasmic reticulum
RT   membrane protein Rcr1 and ubiquitin ligase Rsp5.";
RL   Biosci. Biotechnol. Biochem. 71:249-252(2007).
CC   -!- FUNCTION: Regulates chitin deposition in the cell wall.
CC       {ECO:0000269|PubMed:15590673}.
CC   -!- SUBUNIT: Interacts with PMT4 and WW domain of RSP5.
CC       {ECO:0000269|PubMed:17213653}.
CC   -!- INTERACTION:
CC       P38212; P39940: RSP5; NbExp=3; IntAct=EBI-21381, EBI-16219;
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:15590673}; Single-pass type I membrane protein
CC       {ECO:0000269|PubMed:15590673}.
CC   -!- DOMAIN: Transmembrane domain is required, and the cytoplasmic region
CC       conserved between RCR1 and RCR2 is also essential, to endow resistance
CC       to Congo red.
CC   -!- DOMAIN: The PY motif is recognized directly by the WW domains of RSP5.
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DR   EMBL; Z35874; CAA84941.1; -; Genomic_DNA.
DR   EMBL; AY692680; AAT92699.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07126.1; -; Genomic_DNA.
DR   PIR; S45857; S45857.
DR   RefSeq; NP_009559.1; NM_001178353.1.
DR   AlphaFoldDB; P38212; -.
DR   SMR; P38212; -.
DR   BioGRID; 32706; 78.
DR   IntAct; P38212; 2.
DR   STRING; 4932.YBR005W; -.
DR   iPTMnet; P38212; -.
DR   PaxDb; 4932-YBR005W; -.
DR   PeptideAtlas; P38212; -.
DR   EnsemblFungi; YBR005W_mRNA; YBR005W; YBR005W.
DR   GeneID; 852290; -.
DR   KEGG; sce:YBR005W; -.
DR   AGR; SGD:S000000209; -.
DR   SGD; S000000209; RCR1.
DR   VEuPathDB; FungiDB:YBR005W; -.
DR   eggNOG; ENOG502S7RD; Eukaryota.
DR   GeneTree; ENSGT00940000176721; -.
DR   HOGENOM; CLU_078289_2_1_1; -.
DR   InParanoid; P38212; -.
DR   OMA; SLDTDYG; -.
DR   OrthoDB; 2014620at2759; -.
DR   BioCyc; YEAST:G3O-28993-MONOMER; -.
DR   BioGRID-ORCS; 852290; 2 hits in 10 CRISPR screens.
DR   PRO; PR:P38212; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P38212; Protein.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0006033; P:chitin localization; IMP:SGD.
DR   GO; GO:0016192; P:vesicle-mediated transport; IGI:SGD.
DR   InterPro; IPR020999; Chitin_synth_reg_RCR.
DR   PANTHER; PTHR28187; PROTEIN RCR1-RELATED; 1.
DR   PANTHER; PTHR28187:SF1; PROTEIN RCR1-RELATED; 1.
DR   Pfam; PF12273; RCR; 1.
PE   1: Evidence at protein level;
KW   Cell wall biogenesis/degradation; Endoplasmic reticulum; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..213
FT                   /note="Protein RCR1"
FT                   /id="PRO_0000202466"
FT   TOPO_DOM        1..39
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..213
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          190..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           104..107
FT                   /note="PY motif"
FT   COMPBIAS        190..204
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         82..83
FT                   /note="PP->QA: Reduced interaction with WW domain of RSP5.
FT                   No interaction with WW domain of RSP5; when in association
FT                   with A-105."
FT                   /evidence="ECO:0000269|PubMed:17213653"
FT   MUTAGEN         105
FT                   /note="P->A: Reduced interaction with WW domain of RSP5. No
FT                   interaction with WW domain of RSP5; when in association
FT                   with 82-QA-83."
FT                   /evidence="ECO:0000269|PubMed:17213653"
FT   MUTAGEN         130
FT                   /note="K->A: No effect in conferring Congo red resistance;
FT                   when associated with A-208."
FT                   /evidence="ECO:0000269|PubMed:17213653"
FT   MUTAGEN         208
FT                   /note="K->A: No effect in conferring Congo red resistance;
FT                   when associated with A-130."
FT                   /evidence="ECO:0000269|PubMed:17213653"
SQ   SEQUENCE   213 AA;  23887 MW;  0784FB182C16F1B0 CRC64;
     MGLISYENEA INEVKKADNH HVSKFVTSYY GPSSSSWQSG IWILFVLFVA AVILIILFTF
     VANRRRRRMG RAPIRGTAWL TPPSYRQSQQ QYTGTVQQRT DDYVPEYTET ANEHDLGYYD
     QRGEFHPNDK AAYVAPPPLV QECSSESVNS LERPPAAVVH QANSLDTDYG LTRPSNGRVP
     AVSDTVEQLE RLPGGTTTQE INPPERAKVN ARS
//
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