ID RL18_TRYB2 Reviewed; 193 AA.
AC P50885; Q385Y7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Large ribosomal subunit protein eL18 {ECO:0000305};
DE AltName: Full=60S ribosomal protein L18;
GN Name=RPL18-A; ORFNames=Tb10.6k15.0410;
GN and
GN Name=RPL18-B; ORFNames=Tb11.02.1840;
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8950179; DOI=10.1016/s0167-4781(96)00144-3;
RA Coulter L.J., Hide G.;
RT "The cloning and sequencing of a ribosomal L18 protein from an evolutionary
RT divergent eukaryote, Trypanosoma brucei.";
RL Biochim. Biophys. Acta 1309:69-72(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000312|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C.M., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL18 family.
CC {ECO:0000305}.
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DR EMBL; U47286; AAC47428.1; -; mRNA.
DR EMBL; CM000208; EAN78382.1; -; Genomic_DNA.
DR EMBL; CH464491; EAN79394.1; -; Genomic_DNA.
DR RefSeq; XP_823210.1; XM_818117.1.
DR RefSeq; XP_828506.1; XM_823413.1.
DR PDB; 4V8M; EM; 5.57 A; BI=1-193.
DR PDB; 8OVA; EM; 2.47 A; BI=1-193.
DR PDB; 8OVE; EM; 2.60 A; BI=1-193.
DR PDBsum; 4V8M; -.
DR PDBsum; 8OVA; -.
DR PDBsum; 8OVE; -.
DR AlphaFoldDB; P50885; -.
DR EMDB; EMD-17208; -.
DR EMDB; EMD-17212; -.
DR SMR; P50885; -.
DR IntAct; P50885; 1.
DR STRING; 185431.P50885; -.
DR PaxDb; 5691-EAN78382; -.
DR GeneID; 3661727; -.
DR GeneID; 3664868; -.
DR KEGG; tbr:Tb10.6k15.0410; -.
DR KEGG; tbr:Tb11.02.1840; -.
DR VEuPathDB; TriTrypDB:Tb927.10.9880; -.
DR VEuPathDB; TriTrypDB:Tb927.11.4300; -.
DR eggNOG; KOG1714; Eukaryota.
DR InParanoid; P50885; -.
DR OMA; DHTTKQH; -.
DR OrthoDB; 1122253at2759; -.
DR Proteomes; UP000008524; Chromosome 10.
DR Proteomes; UP000008524; Chromosome 11 Scaffold 1.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IDA:GeneDB.
DR GO; GO:0005840; C:ribosome; ISM:GeneDB.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISM:GeneDB.
DR GO; GO:0006412; P:translation; ISM:GeneDB.
DR Gene3D; 3.100.10.10; -; 1.
DR InterPro; IPR000039; Ribosomal_eL18.
DR InterPro; IPR021132; Ribosomal_eL18/eL18-A/B/_CS.
DR InterPro; IPR021131; Ribosomal_uL15/eL18.
DR InterPro; IPR036227; Ribosomal_uL15/eL18_sf.
DR PANTHER; PTHR10934; 60S RIBOSOMAL PROTEIN L18; 1.
DR PANTHER; PTHR10934:SF2; 60S RIBOSOMAL PROTEIN L18; 1.
DR Pfam; PF17135; Ribosomal_L18; 1.
DR SUPFAM; SSF52080; Ribosomal proteins L15p and L18e; 1.
DR PROSITE; PS01106; RIBOSOMAL_L18E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..193
FT /note="Large ribosomal subunit protein eL18"
FT /id="PRO_0000132779"
FT REGION 158..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 193 AA; 21874 MW; 350856090EAD0388 CRC64;
MGVDLTGVQK KKRVVRHHTY STNPYIKLLI KLYKFLGKRT NSPFNKLIHK RLLKSRNNRA
PISLSRIAVC MRRRTVWLKK GKKSPIAVIV GDVLDDVRMT RIPALRICAL RFSKSARERI
TGAGGECLTF DQLAMMAPTG KNTMLLRGRK SGRESVKHFG AAGVPGSHAK PHVSSRGKER
QRSSKRRHAF RHK
//
