ID RL19_MACFA Reviewed; 196 AA.
AC Q8HXN9; Q4R556;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 2.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Large ribosomal subunit protein eL19 {ECO:0000305};
DE AltName: Full=60S ribosomal protein L19;
GN Name=RPL19; ORFNames=QbsB-11252, QccE-18201;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain stem;
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P84098}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P84098}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P84098}.
CC -!- PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:P84099}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL19 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC21651.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB093677; BAC21651.1; ALT_FRAME; mRNA.
DR EMBL; AB169688; BAE01769.1; -; mRNA.
DR RefSeq; XP_005584063.1; XM_005584006.2.
DR AlphaFoldDB; Q8HXN9; -.
DR SMR; Q8HXN9; -.
DR STRING; 9541.ENSMFAP00000005614; -.
DR Ensembl; ENSMFAT00000035748.2; ENSMFAP00000009649.2; ENSMFAG00000035226.2.
DR GeneID; 101926814; -.
DR KEGG; mcf:101926814; -.
DR CTD; 6143; -.
DR eggNOG; KOG1696; Eukaryota.
DR GeneTree; ENSGT00390000012628; -.
DR OrthoDB; 5483247at2759; -.
DR Proteomes; UP000233100; Chromosome 16.
DR Bgee; ENSMFAG00000035226; Expressed in lymph node and 13 other cell types or tissues.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:Ensembl.
DR GO; GO:0002181; P:cytoplasmic translation; IEA:Ensembl.
DR CDD; cd01417; Ribosomal_L19e_E; 1.
DR Gene3D; 1.10.1200.240; -; 1.
DR Gene3D; 1.10.1650.10; -; 1.
DR HAMAP; MF_01475; Ribosomal_eL19; 1.
DR InterPro; IPR035970; 60S_ribosomal_eL19_sf.
DR InterPro; IPR039547; Ribosomal_eL19.
DR InterPro; IPR023638; Ribosomal_eL19_CS.
DR InterPro; IPR000196; Ribosomal_eL19_dom.
DR InterPro; IPR015972; Ribosomal_eL19_dom1.
DR InterPro; IPR033935; Ribosomal_eL19_euk.
DR PANTHER; PTHR10722; 60S RIBOSOMAL PROTEIN L19; 1.
DR PANTHER; PTHR10722:SF0; 60S RIBOSOMAL PROTEIN L19; 1.
DR Pfam; PF01280; Ribosomal_L19e; 1.
DR SMART; SM01416; Ribosomal_L19e; 1.
DR SUPFAM; SSF48140; Ribosomal protein L19 (L19e); 1.
DR PROSITE; PS00526; RIBOSOMAL_L19E; 1.
PE 2: Evidence at transcript level;
KW Citrullination; Cytoplasm; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT CHAIN 1..196
FT /note="Large ribosomal subunit protein eL19"
FT /id="PRO_0000131170"
FT REGION 157..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 5
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:P84099"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P84098"
FT MOD_RES 16
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:P84099"
FT MOD_RES 38
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:P84099"
FT MOD_RES 164
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P84098"
FT MOD_RES 187
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P84098"
FT CROSSLNK 181
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:P84098"
SQ SEQUENCE 196 AA; 23466 MW; 4AF506393E526216 CRC64;
MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI IRKPVTVHSR
ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR ILRRLLRRYR ESKKIDRHMY
HSLYLKVKGN VFKNKRILME HIHKLKADKA RKKLLADQAE ARRSKTKEAR KRREERLQAK
KEEIIKTLSK EEETKK
//
