ID RL1_LACJO Reviewed; 230 AA.
AC Q74L13;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE RecName: Full=Large ribosomal subunit protein uL1 {ECO:0000255|HAMAP-Rule:MF_01318};
DE AltName: Full=50S ribosomal protein L1 {ECO:0000305};
GN Name=rplA {ECO:0000255|HAMAP-Rule:MF_01318}; OrderedLocusNames=LJ_0411;
OS Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=257314;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNCM I-1225 / La1 / NCC 533;
RX PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT johnsonii NCC 533.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC -!- FUNCTION: Binds directly to 23S rRNA. The L1 stalk is quite mobile in
CC the ribosome, and is involved in E site tRNA release.
CC {ECO:0000255|HAMAP-Rule:MF_01318}.
CC -!- FUNCTION: Protein L1 is also a translational repressor protein, it
CC controls the translation of the L11 operon by binding to its mRNA.
CC {ECO:0000255|HAMAP-Rule:MF_01318}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_01318}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL1 family.
CC {ECO:0000255|HAMAP-Rule:MF_01318}.
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DR EMBL; AE017198; AAS08402.1; -; Genomic_DNA.
DR RefSeq; WP_011161560.1; NC_005362.1.
DR AlphaFoldDB; Q74L13; -.
DR SMR; Q74L13; -.
DR KEGG; ljo:LJ_0411; -.
DR PATRIC; fig|257314.6.peg.436; -.
DR eggNOG; COG0081; Bacteria.
DR HOGENOM; CLU_062853_0_0_9; -.
DR Proteomes; UP000000581; Chromosome.
DR GO; GO:0015934; C:large ribosomal subunit; IEA:InterPro.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00403; Ribosomal_L1; 1.
DR Gene3D; 3.30.190.20; -; 1.
DR Gene3D; 3.40.50.790; -; 1.
DR HAMAP; MF_01318_B; Ribosomal_uL1_B; 1.
DR InterPro; IPR005878; Ribosom_uL1_bac-type.
DR InterPro; IPR002143; Ribosomal_uL1.
DR InterPro; IPR023674; Ribosomal_uL1-like.
DR InterPro; IPR028364; Ribosomal_uL1/biogenesis.
DR InterPro; IPR016095; Ribosomal_uL1_3-a/b-sand.
DR InterPro; IPR023673; Ribosomal_uL1_CS.
DR NCBIfam; TIGR01169; rplA_bact; 1.
DR PANTHER; PTHR36427:SF3; 39S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR36427; 54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL; 1.
DR Pfam; PF00687; Ribosomal_L1; 1.
DR PIRSF; PIRSF002155; Ribosomal_L1; 1.
DR SUPFAM; SSF56808; Ribosomal protein L1; 1.
DR PROSITE; PS01199; RIBOSOMAL_L1; 1.
PE 3: Inferred from homology;
KW Repressor; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding;
KW Translation regulation; tRNA-binding.
FT CHAIN 1..230
FT /note="Large ribosomal subunit protein uL1"
FT /id="PRO_0000125670"
SQ SEQUENCE 230 AA; 24763 MW; A0964020995E0393 CRC64;
MAKHGKRYLE AAKKVDSTKF YSVDEAMKLA KETSYANFDA TIEVAYNLNV DPKQADQQIR
GALVLPNGTG KSKKVVVFAE GPQADQAKEA GADEVGSDDL VEKVQNGYLD FDVVIATPMM
MAKVGRLGRI LGPKGLMPNP KTGTVTMDVA KAVENQKAGQ VEYRVDKQGL IHAPIGKASF
DAEKLAQNFD ALRDVILRAR PASTKGQYVK SVAVSATFGP GIHLDPLNLD
//
