ID RL22L_MOUSE Reviewed; 122 AA.
AC Q9D7S7; Q9CXU8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 149.
DE RecName: Full=Ribosomal protein eL22-like 1 {ECO:0000305};
DE AltName: Full=60S ribosomal protein L22-like 1;
DE AltName: Full=Large ribosomal subunit protein eL22-like 1 {ECO:0000305};
GN Name=Rpl22l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Head, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118 AND SER-120, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118 AND SER-120, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118 AND SER-120, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D7S7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D7S7-2; Sequence=VSP_019380;
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL22 family.
CC {ECO:0000305}.
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DR EMBL; AK008915; BAB25965.1; -; mRNA.
DR EMBL; AK013966; BAB29090.1; -; mRNA.
DR EMBL; BC026533; AAH26533.1; -; mRNA.
DR CCDS; CCDS17278.1; -. [Q9D7S7-1]
DR CCDS; CCDS84615.1; -. [Q9D7S7-2]
DR RefSeq; NP_001334155.1; NM_001347226.1. [Q9D7S7-2]
DR RefSeq; NP_080793.1; NM_026517.2. [Q9D7S7-1]
DR AlphaFoldDB; Q9D7S7; -.
DR SMR; Q9D7S7; -.
DR BioGRID; 212608; 16.
DR IntAct; Q9D7S7; 1.
DR STRING; 10090.ENSMUSP00000043111; -.
DR iPTMnet; Q9D7S7; -.
DR PhosphoSitePlus; Q9D7S7; -.
DR EPD; Q9D7S7; -.
DR jPOST; Q9D7S7; -.
DR MaxQB; Q9D7S7; -.
DR PaxDb; 10090-ENSMUSP00000043111; -.
DR ProteomicsDB; 255158; -. [Q9D7S7-1]
DR ProteomicsDB; 255159; -. [Q9D7S7-2]
DR Pumba; Q9D7S7; -.
DR Antibodypedia; 71210; 60 antibodies from 16 providers.
DR DNASU; 68028; -.
DR Ensembl; ENSMUST00000043867.11; ENSMUSP00000043111.6; ENSMUSG00000039221.11. [Q9D7S7-1]
DR Ensembl; ENSMUST00000194649.2; ENSMUSP00000141510.2; ENSMUSG00000039221.11. [Q9D7S7-2]
DR GeneID; 68028; -.
DR KEGG; mmu:68028; -.
DR UCSC; uc008ouf.1; mouse. [Q9D7S7-1]
DR UCSC; uc008oug.1; mouse. [Q9D7S7-2]
DR AGR; MGI:1915278; -.
DR CTD; 200916; -.
DR MGI; MGI:1915278; Rpl22l1.
DR VEuPathDB; HostDB:ENSMUSG00000039221; -.
DR eggNOG; KOG3434; Eukaryota.
DR GeneTree; ENSGT00940000154509; -.
DR HOGENOM; CLU_105624_0_1_1; -.
DR InParanoid; Q9D7S7; -.
DR OMA; YQLRFYN; -.
DR OrthoDB; 2879766at2759; -.
DR PhylomeDB; Q9D7S7; -.
DR TreeFam; TF313018; -.
DR Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR BioGRID-ORCS; 68028; 11 hits in 75 CRISPR screens.
DR ChiTaRS; Rpl22l1; mouse.
DR PRO; PR:Q9D7S7; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9D7S7; Protein.
DR Bgee; ENSMUSG00000039221; Expressed in mesodermal cell in embryo and 65 other cell types or tissues.
DR ExpressionAtlas; Q9D7S7; baseline and differential.
DR Genevisible; Q9D7S7; MM.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR Gene3D; 3.30.1360.210; -; 1.
DR InterPro; IPR002671; Ribosomal_eL22.
DR InterPro; IPR038526; Ribosomal_eL22_sf.
DR PANTHER; PTHR10064; 60S RIBOSOMAL PROTEIN L22; 1.
DR PANTHER; PTHR10064:SF1; 60S RIBOSOMAL PROTEIN L22-LIKE 1; 1.
DR Pfam; PF01776; Ribosomal_L22e; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..122
FT /note="Ribosomal protein eL22-like 1"
FT /id="PRO_0000240633"
FT MOD_RES 112
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P5R6"
FT MOD_RES 118
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT VAR_SEQ 4
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_019380"
SQ SEQUENCE 122 AA; 14467 MW; 2B536FF82D32A1D3 CRC64;
MAPQKDKKPK KSTWRFHLDL THPVEDGIFD SGNFEQFLRE KVKVNGKTGN LGNVVHIERL
KNKITVVSEK QFSKRYLKYL TKKYLKKNNL RDWLRVVASD KETYELRYFQ ISQDEDGSES
ED
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