ID RLP46_ARATH Reviewed; 811 AA.
AC F4JGB6; O81455;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Receptor-like protein 46 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP46 {ECO:0000303|PubMed:18434605};
DE Flags: Precursor;
GN Name=RLP46 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At4g04220 {ECO:0000312|Araport:AT4G04220};
GN ORFNames=T27D20.9 {ECO:0000312|EMBL:AAC28231.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC28231.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB77890.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF076274; AAC28231.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161499; CAB77890.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82375.1; -; Genomic_DNA.
DR PIR; T01817; T01817.
DR RefSeq; NP_192331.2; NM_116660.3.
DR AlphaFoldDB; F4JGB6; -.
DR SMR; F4JGB6; -.
DR STRING; 3702.F4JGB6; -.
DR GlyCosmos; F4JGB6; 18 sites, No reported glycans.
DR PaxDb; 3702-AT4G04220-1; -.
DR EnsemblPlants; AT4G04220.1; AT4G04220.1; AT4G04220.
DR GeneID; 825737; -.
DR Gramene; AT4G04220.1; AT4G04220.1; AT4G04220.
DR KEGG; ath:AT4G04220; -.
DR Araport; AT4G04220; -.
DR TAIR; AT4G04220; RLP46.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_3_1; -.
DR InParanoid; F4JGB6; -.
DR OMA; VELNYNK; -.
DR OrthoDB; 467767at2759; -.
DR PRO; PR:F4JGB6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JGB6; differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR PANTHER; PTHR46662; DI-GLUCOSE BINDING PROTEIN WITH LEUCINE-RICH REPEAT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46662:SF99; LRRNT_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 6.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF08263; LRRNT_2; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..811
FT /note="Receptor-like protein 46"
FT /id="PRO_5003309756"
FT TOPO_DOM 22..782
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 783..803
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 804..811
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 104..128
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 129..153
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 155..177
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 178..201
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 203..225
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 226..249
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 251..273
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 275..298
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 299..322
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 324..348
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 349..369
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 370..395
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 397..419
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 421..442
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 443..466
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 468..488
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 490..510
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 511..534
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 536..560
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 561..583
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 643..665
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 666..688
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 690..713
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 714..738
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 347
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 376
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 407
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 430
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 499
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 510
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 559
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 583
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 672
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 701
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 747
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 811 AA; 90838 MW; E9241644087B2F29 CRC64;
MSKQCLLSCF LFFCFFIPQL SFSCPQDQRQ SLLEFKNLLI HNIKDNYTAF EELGTWRPNS
DCCKWLRVTC NASSPSKEVI DLNLFLLIPP GLVSSSILRP ILRINSLVGL DVSFNNIQGE
IPGYAFVNLT SLISLDMCCN RFNGSIPHEL FSLTNLQRLD LSRNVIGGTL SGDIKELKNL
QELILDENLI GGAIPSEIGS LVELLTLTLR QNMFNSSIPS SVSRLTKLKT IDLQNNFLSS
KIPDDIGNLV NLSTLSLSMN KLSGGIPSSI HNLKNLETLQ LENNNGLSGE IPAAWLFGLQ
KLKVLRLEGN NKLQWNNNGY VFPQFKLTHL SLRSCGLEGN IPDWLKNQTA LVYLDLSINR
LEGRFPKWLA DLKIRNITLS DNRLTGSLPP NLFQRPSLYY LVLSRNNFSG QIPDTIGESQ
VMVLMLSENN FSGSVPKSIT KIPFLKLLDL SKNRLSGEFP RFRPESYLEW LDISSNEFSG
DVPAYFGGST SMLLMSQNNF SGEFPQNFRN LSYLIRLDLH DNKISGTVAS LISQLSSSVE
VLSLRNNSLK GSIPEGISNL TSLKVLDLSE NNLDGYLPSS LGNLTCMIKS PEPSAMTIRP
YFSSYTDIPN IERLIEIESE DIFSLVVNWK NSKQVLFDRN FYLYTLLDLS KNKLHGEIPT
SLGNLKSLKV LNLSNNEFSG LIPQSFGDLE KVESLDLSHN NLTGEIPKTL SKLSELNTLD
LRNNKLKGRI PESPQLDRLN NPNIYANNSG ICGMQIQVPC FPTQTKQPAE EKEEEDKEEE
ETIFSWNAAA IGCSCGFLIA VVFMSYNELW K
//
