ID RNA14_SCHPO Reviewed; 733 AA.
AC O14233;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 24-JAN-2024, entry version 147.
DE RecName: Full=mRNA 3'-end-processing protein rna14;
GN Name=rna14; ORFNames=SPAC6F12.17;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Component of the cleavage factor IA (CFIA) complex, which is
CC involved in the endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Nucleus and/or cytoplasm. {ECO:0000250}.
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DR EMBL; CU329670; CAB11100.1; -; Genomic_DNA.
DR PIR; T11668; T11668.
DR RefSeq; NP_593303.1; NM_001018733.2.
DR AlphaFoldDB; O14233; -.
DR SMR; O14233; -.
DR BioGRID; 278097; 13.
DR STRING; 284812.O14233; -.
DR iPTMnet; O14233; -.
DR MaxQB; O14233; -.
DR PaxDb; 4896-SPAC6F12-17-1; -.
DR EnsemblFungi; SPAC6F12.17.1; SPAC6F12.17.1:pep; SPAC6F12.17.
DR GeneID; 2541600; -.
DR KEGG; spo:SPAC6F12.17; -.
DR PomBase; SPAC6F12.17; rna14.
DR VEuPathDB; FungiDB:SPAC6F12.17; -.
DR eggNOG; KOG1914; Eukaryota.
DR HOGENOM; CLU_007630_0_1_1; -.
DR InParanoid; O14233; -.
DR OMA; PKRQYFK; -.
DR PhylomeDB; O14233; -.
DR PRO; PR:O14233; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005739; C:mitochondrion; ISS:PomBase.
DR GO; GO:0005848; C:mRNA cleavage stimulating factor complex; ISS:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0180010; P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway; IMP:PomBase.
DR GO; GO:0031123; P:RNA 3'-end processing; IBA:GO_Central.
DR Gene3D; 1.25.40.1040; -; 1.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045243; Rna14-like.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR19980:SF0; CLEAVAGE STIMULATION FACTOR SUBUNIT 3; 1.
DR PANTHER; PTHR19980; RNA CLEAVAGE STIMULATION FACTOR; 1.
DR Pfam; PF05843; Suf; 1.
DR SMART; SM00386; HAT; 9.
DR SUPFAM; SSF48452; TPR-like; 2.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..733
FT /note="mRNA 3'-end-processing protein rna14"
FT /id="PRO_0000238528"
FT REPEAT 85..117
FT /note="HAT 1"
FT REPEAT 119..150
FT /note="HAT 2"
FT REPEAT 158..193
FT /note="HAT 3"
FT REPEAT 204..237
FT /note="HAT 4"
FT REPEAT 269..302
FT /note="HAT 5"
FT REPEAT 312..344
FT /note="HAT 6"
FT REPEAT 523..557
FT /note="HAT 7"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 83926 MW; 8D1398C3B70F53E6 CRC64;
MNSDDNVEAD ASSNIIKDSP KIKEQENTST VNESDVLATS TTASSGVKRK RLPNDLVGQL
RDKIQENPND ISSWYALVEE YGSKGKHEEL RETYEQMLRP FPYVPRVWVD YISSELAFND
FHAVELLFSR CLVKVLSVDL WTLYLSYIRR INPDGEGQSR STITQAYEFV INTIGVDILS
GPIWSEFVDF LRSGPANSTW EQQQKLDHVR RIYQRAITTP IHNIEKLWRD YDAFENSVNR
ATARKFVAEK SPVYMAARAA MRELSNLTEG LRVYDFTFER KYTKVERIAY SRWMNWIKWE
QSDPLDLQHG TMLQNRIAYA FEQAMLYVPL CPQIWLDGFS YFLSISDEQR ALQTIRRGMR
YCPSNFVLHV RYAEHEEANN RTSEIRSTYE SLIAALAREI SQLDSKASSS SESSTDGNPQ
EKKLPEHLVK RKSRLVRQYS LAWCCLINAI RRTEGVKAAR AIFTKARKAP YQSHEIYIAS
AMMEHHCSRD PVIASRIFEL GMRHFGDVPA YVYKYLSYLI AINDETNARA LFEKAIPRIA
ADEAKPIYQK WLDYESNYGD LNAAIALSQR MAVVYPQEST QAIFLSRYGL KDDAEEEERE
TKEAEKIREL SVRLNGGNGF PGHVHNNRED DEVSIASTSS KSNVEMEDTR LLPASLELAN
TQGASNPPTS ALPTVPVPLP SIITEFLDEL PAPQVITGPR IQPTKLIDHI IKSDIPFIRL
RNANAHLKRA RFN
//
