ID RNBP6_HUMAN Reviewed; 1105 AA.
AC O60518; Q5T7X4; Q7Z3V2; Q96E78;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 27-MAR-2024, entry version 176.
DE RecName: Full=Ran-binding protein 6;
DE Short=RanBP6;
GN Name=RANBP6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Goerlich D., Prehn S., Hartmann E.;
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Endometrium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- FUNCTION: May function in nuclear protein import as nuclear transport
CC receptor.
CC -!- INTERACTION:
CC O60518; Q76353; Xeno; NbExp=2; IntAct=EBI-1055771, EBI-6248077;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD97647.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF039023; AAC14260.1; -; mRNA.
DR EMBL; BX537405; CAD97647.1; ALT_INIT; mRNA.
DR EMBL; AL162384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012805; AAH12805.2; -; mRNA.
DR EMBL; BC098406; AAH98406.1; -; mRNA.
DR CCDS; CCDS6467.1; -.
DR RefSeq; NP_001230131.1; NM_001243202.1.
DR RefSeq; NP_001230132.1; NM_001243203.1.
DR RefSeq; NP_036548.1; NM_012416.3.
DR AlphaFoldDB; O60518; -.
DR SMR; O60518; -.
DR BioGRID; 117924; 110.
DR IntAct; O60518; 53.
DR MINT; O60518; -.
DR STRING; 9606.ENSP00000259569; -.
DR GlyGen; O60518; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O60518; -.
DR PhosphoSitePlus; O60518; -.
DR SwissPalm; O60518; -.
DR BioMuta; RANBP6; -.
DR EPD; O60518; -.
DR jPOST; O60518; -.
DR MassIVE; O60518; -.
DR MaxQB; O60518; -.
DR PaxDb; 9606-ENSP00000259569; -.
DR PeptideAtlas; O60518; -.
DR ProteomicsDB; 49455; -.
DR Pumba; O60518; -.
DR Antibodypedia; 24215; 136 antibodies from 27 providers.
DR DNASU; 26953; -.
DR Ensembl; ENST00000259569.6; ENSP00000259569.5; ENSG00000137040.10.
DR GeneID; 26953; -.
DR KEGG; hsa:26953; -.
DR MANE-Select; ENST00000259569.6; ENSP00000259569.5; NM_012416.4; NP_036548.1.
DR UCSC; uc003zjr.4; human.
DR AGR; HGNC:9851; -.
DR CTD; 26953; -.
DR DisGeNET; 26953; -.
DR GeneCards; RANBP6; -.
DR HGNC; HGNC:9851; RANBP6.
DR HPA; ENSG00000137040; Low tissue specificity.
DR neXtProt; NX_O60518; -.
DR OpenTargets; ENSG00000137040; -.
DR PharmGKB; PA34212; -.
DR VEuPathDB; HostDB:ENSG00000137040; -.
DR eggNOG; KOG2171; Eukaryota.
DR GeneTree; ENSGT00940000162767; -.
DR HOGENOM; CLU_003794_0_0_1; -.
DR InParanoid; O60518; -.
DR OMA; DSCYQDD; -.
DR OrthoDB; 24319at2759; -.
DR PhylomeDB; O60518; -.
DR TreeFam; TF300344; -.
DR PathwayCommons; O60518; -.
DR SignaLink; O60518; -.
DR BioGRID-ORCS; 26953; 20 hits in 1160 CRISPR screens.
DR ChiTaRS; RANBP6; human.
DR GenomeRNAi; 26953; -.
DR Pharos; O60518; Tdark.
DR PRO; PR:O60518; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; O60518; Protein.
DR Bgee; ENSG00000137040; Expressed in endothelial cell and 210 other cell types or tissues.
DR ExpressionAtlas; O60518; baseline and differential.
DR Genevisible; O60518; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR041653; Importin_rep_4.
DR InterPro; IPR041389; Importin_rep_6.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF16; RAN-BINDING PROTEIN 6; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF18808; Importin_rep_4; 1.
DR Pfam; PF18829; Importin_rep_6; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Cytoplasm; Nucleus; Protein transport;
KW Reference proteome; Repeat; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CHAIN 2..1105
FT /note="Ran-binding protein 6"
FT /id="PRO_0000120779"
FT REPEAT 219..257
FT /note="HEAT 1"
FT REPEAT 361..399
FT /note="HEAT 2"
FT REPEAT 402..440
FT /note="HEAT 3"
FT REPEAT 444..483
FT /note="HEAT 4"
FT REPEAT 866..905
FT /note="HEAT 5"
FT REPEAT 908..946
FT /note="HEAT 6"
FT REPEAT 949..987
FT /note="HEAT 7"
FT REGION 333..383
FT /note="Ran-GTP binding"
FT /evidence="ECO:0000250"
FT COILED 806..842
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CONFLICT 2
FT /note="A -> P (in Ref. 1; AAC14260)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1105 AA; 124714 MW; 9434C69D548DF150 CRC64;
MAATASAGVP ATVSEKQEFY QLLKNLINPS CMVRRQAEEI YENIPGLCKT TFLLDAVRNR
RAGYEVRQMA AALLRRLLSS GFEEVYPNLP ADVQRDVKIE LILAVKLETH ASMRKKLCDI
FAVLARNLID EDGTNHWPEG LKFLIDSIYS KNVVLWEVAL HVFWHFPGIF GTQERHDLDI
IKRLLDQCIQ DQEHPAIRTL SARAAAAFVL ANENNIALFK DFADLLPGIL QAVNDSCYQD
DDSVLESLVE IADTVPKYLG PYLEDTLQLS LKLCGDSRLS NLQRQLALEV IVTLSETATP
MLKKHTNIIA QAVPHILAMM VDLQDDEDWV NADEMEEDDF DSNAVAAESA LDRLACGLGG
KVVLPMTKEH IMQMLQSPDW KYRHAGLMAL SAIGEGCHQQ MESILDETVN SVLLFLQDPH
PRVRAAACTT LGQMATDFAP NFQKKFHETV IAALLRTMEN QGNQRVQSHA ASALIIFIED
CPKSLLVLYV DSMVKNLHSV LVIKLQELIR NGTKLALEQL VTTIASVADT IEEKFVPYYD
IFMPSLKHIV ELAVQKELKL LRGKTIECIS HIGLAVGKEK FMQDASNVMQ LLLKTQSDLN
NMEDDDPQTS YMVSAWARMC KILGKDFQQY LPLVIEPLIK TASAKPDVAL LDTQDVENMS
DDDGWQFVNL GDQQSFGIKT SGLEAKATAC QMLVYYAKEL REGFVEYTEQ VVKLMVPLLK
FYFHDNVRVA AAESMPFLLE CARIRGPEYL AQMWQFICDP LIKAIGTEPD TDVLSEIMNS
FAKSIEVMGD GCLNDEHLEE LGGILKAKLE GHFKNQELRQ VKRQEENYDQ QVEMSLQDED
ECDVYILTKV SDILHSLFST YKEKILPWFE QLLPLIVNLI CSSRPWPDRQ WGLCIFDDII
EHCSPTSFKY VEYFRWPMLL NMRDNNPEVR QAAAYGLGVM AQFGGDDYRS LCSEAVPLLV
KVIKCANSKT KKNVIATENC ISAIGKILKF KPNCVNVDEV LPHWLSWLPL HEDKEEAIQT
LSFLCDLIES NHPVVIGPNN SNLPKIISII AEGKINETIN YEDPCAKRLA NVVRQVQTSE
DLWLECVSQL DDEQQEALQE LLNFA
//
