ID RNY_FLAPJ Reviewed; 520 AA.
AC A6GYR0;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Ribonuclease Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE Short=RNase Y {ECO:0000255|HAMAP-Rule:MF_00335};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00335};
GN Name=rny {ECO:0000255|HAMAP-Rule:MF_00335}; OrderedLocusNames=FP1146;
OS Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 /
OS JIP02/86).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=402612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86;
RX PubMed=17592475; DOI=10.1038/nbt1313;
RA Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B.,
RA Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F.,
RA Claverol S., Dumetz F., Le Henaff M., Benmansour A.;
RT "Complete genome sequence of the fish pathogen Flavobacterium
RT psychrophilum.";
RL Nat. Biotechnol. 25:763-769(2007).
CC -!- FUNCTION: Endoribonuclease that initiates mRNA decay.
CC {ECO:0000255|HAMAP-Rule:MF_00335}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00335};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00335}.
CC -!- SIMILARITY: Belongs to the RNase Y family. {ECO:0000255|HAMAP-
CC Rule:MF_00335}.
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DR EMBL; AM398681; CAL43233.1; -; Genomic_DNA.
DR RefSeq; WP_011963284.1; NC_009613.3.
DR RefSeq; YP_001296044.1; NC_009613.3.
DR AlphaFoldDB; A6GYR0; -.
DR SMR; A6GYR0; -.
DR STRING; 402612.FP1146; -.
DR EnsemblBacteria; CAL43233; CAL43233; FP1146.
DR GeneID; 66553050; -.
DR KEGG; fps:FP1146; -.
DR PATRIC; fig|402612.5.peg.1158; -.
DR eggNOG; COG1418; Bacteria.
DR HOGENOM; CLU_028328_1_0_10; -.
DR OrthoDB; 9803205at2; -.
DR Proteomes; UP000006394; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00077; HDc; 1.
DR CDD; cd22431; KH-I_RNaseY; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR HAMAP; MF_00335; RNase_Y; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR017705; Ribonuclease_Y.
DR InterPro; IPR022711; RNase_Y_N.
DR NCBIfam; TIGR00277; HDIG; 1.
DR NCBIfam; TIGR03319; RNase_Y; 1.
DR PANTHER; PTHR12826; RIBONUCLEASE Y; 1.
DR PANTHER; PTHR12826:SF15; RIBONUCLEASE Y; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF12072; RNase_Y_N; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Endonuclease; Hydrolase; Membrane; Nuclease;
KW Reference proteome; RNA-binding; Transmembrane; Transmembrane helix.
FT CHAIN 1..520
FT /note="Ribonuclease Y"
FT /id="PRO_0000344875"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT DOMAIN 210..276
FT /note="KH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00335"
FT DOMAIN 336..429
FT /note="HD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01175"
SQ SEQUENCE 520 AA; 57697 MW; 078B3BBC7A6DE282 CRC64;
MDIITIIIAV IAGIGGGFGI SKFLEKSGVS NLIKNAKKEA SSILKDANLE GENIKKDKIL
QAKEKFIELK SEHEQVILTR DRKVAEVEKR VRDKESQVSG ELSKAKKIND DFEAKTNEYN
TKLENLEKKQ VEVEKMHKSQ LQQLEVISGL STEEAKNQLI EGLKSEAKTQ AMAHIQETIE
EAKLTAQQEA KKIIISTIQR VGTEEAVENC VSVFNIESDD VKGRIIGREG RNIRAIEAAT
GVEIIVDDTP EAIILSCFDP VRREIARLAL HKLVTDGRIH PARIEEVVAK TTKQIDDEII
EVGKRTVIDL GIHGLHPELI KVVGRMKYRS SYGQNLLQHS REVSKLCGIM AAELGLNVKL
AKRAGLLHDI GKVPDAESDL PHALLGMQWA EKYGEKEEVC NAIGAHHDEI EMKSLLSPIV
QVCDAISGAR PGARRQVLDS YIQRLKDLEE VAYGFNGVKS AYAIQAGREL RVIVESEKVS
DDNASNLSFE ISQKIQTEMT YPGQVKVTVI RETRAVNIAK
//
