ID RS13_DICDI Reviewed; 151 AA.
AC Q54PH8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 109.
DE RecName: Full=Small ribosomal subunit protein uS15 {ECO:0000305};
DE AltName: Full=40S ribosomal protein S13;
GN Name=rps13; ORFNames=DDB_G0284533;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the small ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. Part of the small subunit (SSU) processome, first
CC precursor of the small eukaryotic ribosomal subunit. During the
CC assembly of the SSU processome in the nucleolus, many ribosome
CC biogenesis factors, an RNA chaperone and ribosomal proteins associate
CC with the nascent pre-rRNA and work in concert to generate RNA folding,
CC modifications, rearrangements and cleavage as well as targeted
CC degradation of pre-ribosomal RNA by the RNA exosome.
CC {ECO:0000250|UniProtKB:P62277}.
CC -!- SUBUNIT: Component of the small ribosomal subunit. Part of the small
CC subunit (SSU) processome, composed of more than 70 proteins and the RNA
CC chaperone small nucleolar RNA (snoRNA) U3.
CC {ECO:0000250|UniProtKB:P62277}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62277}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:P62277}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS15 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000066; EAL65193.1; -; Genomic_DNA.
DR RefSeq; XP_638554.1; XM_633462.1.
DR AlphaFoldDB; Q54PH8; -.
DR SMR; Q54PH8; -.
DR STRING; 44689.Q54PH8; -.
DR PaxDb; 44689-DDB0230055; -.
DR EnsemblProtists; EAL65193; EAL65193; DDB_G0284533.
DR GeneID; 8624647; -.
DR KEGG; ddi:DDB_G0284533; -.
DR dictyBase; DDB_G0284533; rps13.
DR eggNOG; KOG0400; Eukaryota.
DR HOGENOM; CLU_090139_2_0_1; -.
DR InParanoid; Q54PH8; -.
DR OMA; EEHPKDM; -.
DR PhylomeDB; Q54PH8; -.
DR Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DDI-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DDI-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DDI-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q54PH8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; ISS:UniProtKB.
DR GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd00353; Ribosomal_S15p_S13e; 1.
DR Gene3D; 4.10.860.130; -; 1.
DR Gene3D; 1.10.287.10; S15/NS1, RNA-binding; 1.
DR HAMAP; MF_01343_A; Ribosomal_uS15_A; 1.
DR InterPro; IPR000589; Ribosomal_uS15.
DR InterPro; IPR023029; Ribosomal_uS15_arc_euk.
DR InterPro; IPR012606; Ribosomal_uS15_N.
DR InterPro; IPR009068; uS15_NS1_RNA-bd_sf.
DR PANTHER; PTHR11885:SF6; 40S RIBOSOMAL PROTEIN S13; 1.
DR PANTHER; PTHR11885; RIBOSOMAL PROTEIN S15P/S13E; 1.
DR Pfam; PF08069; Ribosomal_S13_N; 1.
DR Pfam; PF00312; Ribosomal_S15; 1.
DR SMART; SM01386; Ribosomal_S13_N; 1.
DR SMART; SM01387; Ribosomal_S15; 1.
DR SUPFAM; SSF47060; S15/NS1 RNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..151
FT /note="Small ribosomal subunit protein uS15"
FT /id="PRO_0000319548"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 151 AA; 16876 MW; AA857C0DFC8321AD CRC64;
MGRMHSNGKG ISGSSLPYNR KPHAWTKPTA SEVCETVCKL AKRGYTPSKI GSSLRDSLGV
AQVKNVTGSK ILRILKVNGL APTIPEDLYH LIKKAVTINK HLQRARKDYD GKFHLRLVES
RIHRLTRPYR KNGTLAPNWK YESNNASTLV A
//
