ID RS4X_DANRE Reviewed; 263 AA.
AC Q642H9;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 27-MAR-2024, entry version 123.
DE RecName: Full=Small ribosomal subunit protein eS4 {ECO:0000305};
DE AltName: Full=40S ribosomal protein S4, X isoform;
GN Name=rps4x; Synonyms=rps4; ORFNames=zgc:92076;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the small ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. Part of the small subunit (SSU) processome, first
CC precursor of the small eukaryotic ribosomal subunit. During the
CC assembly of the SSU processome in the nucleolus, many ribosome
CC biogenesis factors, an RNA chaperone and ribosomal proteins associate
CC with the nascent pre-rRNA and work in concert to generate RNA folding,
CC modifications, rearrangements and cleavage as well as targeted
CC degradation of pre-ribosomal RNA by the RNA exosome.
CC {ECO:0000250|UniProtKB:P62701}.
CC -!- SUBUNIT: Component of the small ribosomal subunit. Part of the small
CC subunit (SSU) processome, composed of more than 70 proteins and the RNA
CC chaperone small nucleolar RNA (snoRNA) U3.
CC {ECO:0000250|UniProtKB:P62701}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62701}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:P62701}. Note=Localized in
CC cytoplasmic mRNP granules containing untranslated mRNAs.
CC {ECO:0000250|UniProtKB:P62701}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC {ECO:0000305}.
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DR EMBL; BC081584; AAH81584.1; -; mRNA.
DR RefSeq; NP_001005589.1; NM_001005589.1.
DR PDB; 7OYA; EM; 3.20 A; E2=1-263.
DR PDB; 7OYB; EM; 2.40 A; E2=1-263.
DR PDBsum; 7OYA; -.
DR PDBsum; 7OYB; -.
DR AlphaFoldDB; Q642H9; -.
DR EMDB; EMD-13111; -.
DR EMDB; EMD-13112; -.
DR SMR; Q642H9; -.
DR STRING; 7955.ENSDARP00000108089; -.
DR PaxDb; 7955-ENSDARP00000108089; -.
DR GeneID; 449547; -.
DR KEGG; dre:449547; -.
DR AGR; ZFIN:ZDB-GENE-040927-19; -.
DR CTD; 6191; -.
DR ZFIN; ZDB-GENE-040927-19; rps4x.
DR eggNOG; KOG0378; Eukaryota.
DR HOGENOM; CLU_060400_1_0_1; -.
DR InParanoid; Q642H9; -.
DR OMA; RKDYKFP; -.
DR OrthoDB; 5471107at2759; -.
DR PhylomeDB; Q642H9; -.
DR TreeFam; TF300612; -.
DR Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DRE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-DRE-72649; Translation initiation complex formation.
DR Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DRE-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DRE-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DRE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q642H9; -.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000014690; Expressed in tail bud paraxial mesoderm and 28 other cell types or tissues.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0032040; C:small-subunit processome; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IMP:ZFIN.
DR GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd06087; KOW_RPS4; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.740; -; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR HAMAP; MF_00485; Ribosomal_eS4; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR000876; Ribosomal_eS4.
DR InterPro; IPR032277; Ribosomal_eS4_C.
DR InterPro; IPR013845; Ribosomal_eS4_central_region.
DR InterPro; IPR038237; Ribosomal_eS4_central_sf.
DR InterPro; IPR041982; Ribosomal_eS4_KOW.
DR InterPro; IPR013843; Ribosomal_eS4_N.
DR InterPro; IPR018199; Ribosomal_eS4_N_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11581; 30S/40S RIBOSOMAL PROTEIN S4; 1.
DR PANTHER; PTHR11581:SF0; 40S RIBOSOMAL PROTEIN S4; 1.
DR Pfam; PF16121; 40S_S4_C; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF00900; Ribosomal_S4e; 1.
DR Pfam; PF08071; RS4NT; 1.
DR PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR PROSITE; PS00528; RIBOSOMAL_S4E; 1.
DR PROSITE; PS50889; S4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P62701"
FT CHAIN 2..263
FT /note="Small ribosomal subunit protein eS4"
FT /id="PRO_0000130824"
FT DOMAIN 42..105
FT /note="S4 RNA-binding"
SQ SEQUENCE 263 AA; 29688 MW; 6896BC99E0FC0AB6 CRC64;
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE
VKKICMQRFI KIDGKVRTDI TYPTGFMDVV SIEKTGENFR LIYDVKGRFT VHRITNEEAK
YKLCKVRKIL IGTKGIPHLV THDARTIRYP DPLIKVNDTI RIDLDTGKIT DFIKFETGNM
CMVTGGANLG RIGVITNREK HPGSFDVVHV KDSIGNSFAT RLSNIFVIGK GNKPWVSLPR
GKGVRLTIAE ERDKRLAAKQ SSS
//
