ID RTEL1_DROGR Reviewed; 986 AA.
AC B4JNS2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=Regulator of telomere elongation helicase 1 homolog {ECO:0000255|HAMAP-Rule:MF_03065};
DE EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_03065};
GN ORFNames=GH24089;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: ATP-dependent DNA helicase implicated in DNA repair and the
CC maintenance of genomic stability. Acts as an anti-recombinase to
CC counteract toxic recombination and limit crossover during meiosis.
CC Regulates meiotic recombination and crossover homeostasis by physically
CC dissociating strand invasion events and thereby promotes noncrossover
CC repair by meiotic synthesis dependent strand annealing (SDSA) as well
CC as disassembly of D loop recombination intermediates.
CC {ECO:0000255|HAMAP-Rule:MF_03065}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_03065};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03065}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03065}.
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DR EMBL; CH916371; EDV92365.1; -; Genomic_DNA.
DR RefSeq; XP_001992658.1; XM_001992622.1.
DR AlphaFoldDB; B4JNS2; -.
DR SMR; B4JNS2; -.
DR STRING; 7222.B4JNS2; -.
DR eggNOG; KOG1132; Eukaryota.
DR HOGENOM; CLU_006515_4_0_1; -.
DR InParanoid; B4JNS2; -.
DR OMA; GNCATIV; -.
DR PhylomeDB; B4JNS2; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0036098; P:male germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd17970; DEAHc_FancJ; 1.
DR CDD; cd13932; HN_RTEL1; 1.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 1.20.1160.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_03065; RTEL1; 1.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR030845; RTEL1.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF34; REGULATOR OF TELOMERE ELONGATION HELICASE 1; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase;
KW Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..986
FT /note="Regulator of telomere elongation helicase 1 homolog"
FT /id="PRO_0000370622"
FT DOMAIN 7..326
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT MOTIF 254..257
FT /note="DEAH box"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 148
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 166
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 175
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 211
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT MOD_RES 875
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 986 AA; 109960 MW; 1107B6A97E125818 CRC64;
MPENIIAGIP VHFPFEPYDV QRAYMEKVII CLRDGTNGVL ESPTGTGKTL SLLCSTLGWI
RTRQSEVQLN MQKLQHDQQT QLTGAAGAGA AMGSEIAAVI GKSNNWGVPK VIYASRTHSQ
LTQAMRELKR TAYANMRAVV LGSRDQLCIH PDVMREQGNS NKVNMCKLKV HAKSCTFQLR
VESKKDHPDF RGPSIMDIED LVKVGQRLKM CPYFASKELV NSADITFMPY NYLLDPKARK
ANKIELSNAI VILDEGHNIE KICEESASVQ IRSSDVAIAI EDVTHIMKIF TSSSDSQDTA
GPDEPKDFTI DDLTLLKEML LELEKAIDGV IVDNKADGAT YPASYMYELL GKANFTHGNC
ATIVALLDKL VQYLMVASQH SMLRKGGSFM VLADLLNIVF ANKGDIMSKV SCSFKVHAEI
EESKQSQTNN KAQTGWLGKG NNNAASSASK TGRIINFWCF NPGFGMEQLL NTHVRSVILT
SGTLAPLKPL IAELAIPVAQ HLENPHIVNE AQVYVKIIGT GPDREQLISN YKNRDNPKYI
SSLGQTILNV SRIVPDGLLV FFPSYPMLNQ CVDAWQASGL WADISSRKPI FLEPRGKDQF
TSTMEEFYQA IRDSKGACFM AVCRGKVSEG LDFADRNGRA VIITGLPFPP LKDPKVILKR
RYLETNRTRE NQLLSGNEWY NLEATRAVNQ AIGRVIRHRN DYGAILLCDA RFQDASQVQQ
LSKWIRNHLG ARPQSSPFGP IVRELRQFFK HAEQTIVQPV ERAVEPVLHT ICSKKEDQLT
LAPITQIKRE PGNTGTSKFQ LASELAAKVE MANSIKTWTP ADYANAAGRN AQSPKAPNPM
DFMSRLNSNV TSIDFNADSG RDLVKIHKRE RSSPTFHNES MGSKKRYRLI NNIAQSELKE
APESRADFLR EVRSVINSDQ FRSFGKALLA YKTGGDDSFE TLMLLLLDVM GAPKLRYLLH
GMRRYLKNEH KSEFDVRLAS LEAAQL
//
