ID RTM3_ARATH Reviewed; 301 AA.
AC D5K228; Q9M2I1;
DT 11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Protein RESTRICTED TEV MOVEMENT 3;
DE Short=Protein RTM3;
DE AltName: Full=MATH domain and coiled-coil domain-containing protein RTM3;
DE AltName: Full=Restricted tobacco etch virus movement protein 3;
GN Name=RTM3; OrderedLocusNames=At3g58350; ORFNames=F9D24.260;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=cv. Wassilewskija, and cv. Wt-5;
RX PubMed=20478894; DOI=10.1098/rstb.2010.0044;
RA Lalic J., Agudelo-Romero P., Carrasco P., Elena S.F.;
RT "Adaptation of tobacco etch potyvirus to a susceptible ecotype of
RT Arabidopsis thaliana capacitates it for systemic infection of resistant
RT ecotypes.";
RL Philos. Trans. R. Soc. Lond., B, Biol. Sci. 365:1997-2007(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Ita-0, cv. Jea, cv. Kn-0, cv. Ler-2, cv. N13 Konchezero,
RC cv. Stw-0, and cv. Wassilewskija-2;
RX PubMed=22723957; DOI=10.1371/journal.pone.0039169;
RA Cosson P., Schurdi-Levraud V., Le Q.H., Sicard O., Caballero M., Roux F.,
RA Le Gall O., Candresse T., Revers F.;
RT "The RTM resistance to potyviruses in Arabidopsis thaliana: natural
RT variation of the RTM genes and evidence for the implication of additional
RT genes.";
RL PLoS ONE 7:E39169-E39169(2012).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17633013; DOI=10.1007/978-0-387-70630-6_1;
RA Zapata J.M., Martinez-Garcia V., Lefebvre S.;
RT "Phylogeny of the TRAF/MATH domain.";
RL Adv. Exp. Med. Biol. 597:1-24(2007).
RN [6]
RP GENE FAMILY, FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF GLU-284,
RP INTERACTION WITH RTM1, AND SUBUNIT.
RX PubMed=20584941; DOI=10.1104/pp.110.155754;
RA Cosson P., Sofer L., Le Q.H., Leger V., Schurdi-Levraud V., Whitham S.A.,
RA Yamamoto M.L., Gopalan S., Le Gall O., Candresse T., Carrington J.C.,
RA Revers F.;
RT "RTM3, which controls long-distance movement of potyviruses, is a member of
RT a new plant gene family encoding a meprin and TRAF homology domain-
RT containing protein.";
RL Plant Physiol. 154:222-232(2010).
RN [7]
RP REVIEW.
RX PubMed=20930558; DOI=10.4161/psb.5.10.13244;
RA Cosson P., Sofer L., Schurdi-Levraud V., Revers F.;
RT "A member of a new plant gene family encoding a meprin and TRAF homology
RT (MATH) domain-containing protein is involved in restriction of long
RT distance movement of plant viruses.";
RL Plant Signal. Behav. 5:1321-1323(2010).
CC -!- FUNCTION: Required for the restriction of long-distance movement of the
CC pathogenic tobacco etch virus (TEV) without causing a hypersensitive
CC response or inducing systemic acquired resistance.
CC {ECO:0000269|PubMed:20478894, ECO:0000269|PubMed:20584941}.
CC -!- SUBUNIT: Self-interacts. Interacts with RTM1.
CC {ECO:0000269|PubMed:20584941}.
CC -!- DISRUPTION PHENOTYPE: Susceptible to systemic infection by tobacco etch
CC virus (TEV) and to some isolates of lettuce mosaic virus (LMV) and plum
CC pox virus (PPV). {ECO:0000269|PubMed:20584941}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB68173.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; GU396210; ADE43100.1; -; Genomic_DNA.
DR EMBL; GU396220; ADE43110.1; -; Genomic_DNA.
DR EMBL; FR681938; CBW45910.1; -; Genomic_DNA.
DR EMBL; FR681941; CBW45913.1; -; Genomic_DNA.
DR EMBL; FR681944; CBW45916.1; -; Genomic_DNA.
DR EMBL; FR681947; CBW45919.1; -; Genomic_DNA.
DR EMBL; FR681960; CBW45932.1; -; Genomic_DNA.
DR EMBL; FR681961; CBW45933.1; -; Genomic_DNA.
DR EMBL; FR681962; CBW45934.1; -; Genomic_DNA.
DR EMBL; AL137081; CAB68173.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE79772.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65779.1; -; Genomic_DNA.
DR PIR; T45995; T45995.
DR RefSeq; NP_001319792.1; NM_001339919.1.
DR RefSeq; NP_567063.1; NM_115697.1.
DR AlphaFoldDB; D5K228; -.
DR SMR; D5K228; -.
DR BioGRID; 10319; 2.
DR IntAct; D5K228; 1.
DR STRING; 3702.D5K228; -.
DR PaxDb; 3702-AT3G58350-1; -.
DR ProteomicsDB; 226697; -.
DR EnsemblPlants; AT3G58350.1; AT3G58350.1; AT3G58350.
DR EnsemblPlants; AT3G58350.2; AT3G58350.2; AT3G58350.
DR GeneID; 825004; -.
DR Gramene; AT3G58350.1; AT3G58350.1; AT3G58350.
DR Gramene; AT3G58350.2; AT3G58350.2; AT3G58350.
DR KEGG; ath:AT3G58350; -.
DR Araport; AT3G58350; -.
DR TAIR; AT3G58350; RTM3.
DR eggNOG; KOG1987; Eukaryota.
DR HOGENOM; CLU_026537_0_0_1; -.
DR InParanoid; D5K228; -.
DR OMA; CPLNEIH; -.
DR OrthoDB; 1222791at2759; -.
DR PRO; PR:D5K228; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; D5K228; baseline and differential.
DR Genevisible; D5K228; AT.
DR GO; GO:0043621; F:protein self-association; IDA:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; IMP:UniProtKB.
DR GO; GO:0009615; P:response to virus; IMP:TAIR.
DR GO; GO:0046741; P:transport of virus in host, tissue to tissue; TAS:UniProtKB.
DR CDD; cd00121; MATH; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR008974; TRAF-like.
DR PANTHER; PTHR46236:SF7; PROTEIN RESTRICTED TEV MOVEMENT 3; 1.
DR PANTHER; PTHR46236; TRAF-LIKE SUPERFAMILY PROTEIN; 1.
DR Pfam; PF00917; MATH; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Plant defense; Reference proteome.
FT CHAIN 1..301
FT /note="Protein RESTRICTED TEV MOVEMENT 3"
FT /id="PRO_0000429301"
FT DOMAIN 6..134
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT COILED 235..289
FT /evidence="ECO:0000255"
FT MUTAGEN 284
FT /note="E->K: In rtm3-1; susceptible to systemic infection
FT by viruses."
FT /evidence="ECO:0000269|PubMed:20584941"
SQ SEQUENCE 301 AA; 34072 MW; 1CFC7A9E14EBD321 CRC64;
MGKQFDKKIT WTIKNFASLL SDLIYSDHFV VGGCKWHLRA YPKGYNNANS LSLFLGVAVP
TSLPSGWRRH TKFRLTLVNQ LSDKLSQSKL NELEQWFDEK TTNWGLSSMC PLNEIHAKDS
GFLLNGELKI VVEIKVLETI GKLDVTEETS TITETVDVNG FQLLPSQAKS VSRMFAKHPE
LASDLRPKNP NLRTGYMSLL LSLIETLSQL PQQMSKDDLL DAYDALGSMR DAGFKLDWLE
KKLYEVSEKK ENEEASETGL QEMEEELKDM KQKCLEMEAL VEKEKAKVST AKAPISFDDI
V
//
