ID S0F1D1_SALSA Unreviewed; 1036 AA.
AC S0F1D1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Toll-like receptor 8 {ECO:0000313|EMBL:CCX35460.1, ECO:0000313|RefSeq:XP_013983811.1};
GN Name=TLR8b2 {ECO:0000313|EMBL:CCX35460.1};
GN Synonyms=LOC106563113 {ECO:0000313|RefSeq:XP_013983811.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:CCX35460.1};
RN [1] {ECO:0000313|EMBL:CCX35460.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:CCX35460.1};
RX PubMed=23747412; DOI=10.1016/j.dci.2013.05.013;
RA Lee P.T., Zou J., Holland J.W., Martin S.A., Kanellos T., Secombes C.J.;
RT "Identification and characterization of TLR7, TLR8a2, TLR8b1 and TLR8b2
RT genes in Atlantic salmon (Salmo salar).";
RL Dev. Comp. Immunol. 41:295-305(2013).
RN [2] {ECO:0000313|EMBL:CCX35460.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:CCX35460.1};
RA Lee P.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_013983811.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_013983811.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; HF970588; CCX35460.1; -; mRNA.
DR RefSeq; XP_013983811.1; XM_014128336.1.
DR STRING; 8030.ENSSSAP00000057976; -.
DR PaxDb; 8030-ENSSSAP00000057976; -.
DR Ensembl; ENSSSAT00000087665; ENSSSAP00000057976; ENSSSAG00000054795.
DR GeneID; 106563113; -.
DR KEGG; sasa:106563113; -.
DR OMA; VRPLCLE; -.
DR OrthoDB; 4071419at2759; -.
DR Proteomes; UP000087266; Chromosome ssa11.
DR Bgee; ENSSSAG00000054795; Expressed in head kidney and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF1; TOLL-LIKE RECEPTOR 8; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:CCX35460.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1036
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010848820"
FT DOMAIN 870..1017
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1036 AA; 118892 MW; BC3C6488F21A9F55 CRC64;
MKEQHWCPLY TSFQRLLLLL VLLCLSPSCS GRTWAQRKLP CDVISLNHSL AFNCSHRKLL
QVPHDISWNA TELDLSSNQI KILSSSSFWN LQNLTLLDLS HNFNPQEHPL KIEDQTFSML
DQLEALLLDG NGLCTVPRGL PSGLQILFLR YNDIRTVTPE NFRDIPRIKV IRLSDNCQGS
VCNGTLDIAN HTFSSLTNLT NLTLSFNRLK AIPHFLPPSL QLLKLERNLI THIHQHDLSA
LTNLSALDFS GNCPVCSNTP FLCFPCNTPN GALQIHPDAF RKLSQLQELR LSGNSLEHLQ
TTWFENLTNL RYLYLSFNRL VGEIANGDFL SVLPFVEVMD LSYNNAGQNS HNLSLSKNFS
KLASLKTLHL ENYVFSALHK NHLEPLYSLA NLSVLNLATN FIYWTDLSLF EKFHNLSSVG
LSENSLTFLS KRADALSVNG YGWGYEPDID RYEPLIHKDE FYRRHLPNIK PECLAYGPVL
DLSKNNIFHI NPDMLQGLNN TACLNLSSNF IGDMFNGSEF VHFSKLKYLD LSQNKVYLRF
EHAFSELTAL EVLDLSYNKH YFLVAGLNHS LAFLENLGSL KVLNLSWNEI STLTDKAMSS
NSLQELNFQG NRLDIMWNKG LDFNHLFREL NNLTSLDLSY NQLHHIPSEV YDNFPKTLRH
LTLSKNGLED FNWTRLTQLP HLEELDLSKN KLERVALTFS TLNSSLRLLD LSHNRISQLV
PGFLRGARSL YVLDLSFNLL ELINQTTFES GAENNLQQLS LQGNPLHCTC DLLEFHMWMR
SNEVELPLLA IEVTCDMPME RRGRSVLSYD IEECVKDDNA MAFCILTLLV VVHLLLVSLT
AHLFYWDLSY ILYYCLAKLK HQCLLHDTDC VYDAFVMYDT TDPLASDWVL NHLRVELEER
GERVRPLCLE ERDWMPGMPI MDNLSNSVRQ SRKTVFVLTE GFLSRGVVKM AALLVQQRLV
EEGVDAMVLL LLQPQVLRRS RILHLRRRLC RRSVLEWPAT AGPAAQRWFW HHLKRAIRKD
QRATHASLHG TYFTGR
//