GenomeNet

Database: UniProt
Entry: S0F1D1_SALSA
LinkDB: S0F1D1_SALSA
Original site: S0F1D1_SALSA 
ID   S0F1D1_SALSA            Unreviewed;      1036 AA.
AC   S0F1D1;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   SubName: Full=Toll-like receptor 8 {ECO:0000313|EMBL:CCX35460.1, ECO:0000313|RefSeq:XP_013983811.1};
GN   Name=TLR8b2 {ECO:0000313|EMBL:CCX35460.1};
GN   Synonyms=LOC106563113 {ECO:0000313|RefSeq:XP_013983811.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|EMBL:CCX35460.1};
RN   [1] {ECO:0000313|EMBL:CCX35460.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:CCX35460.1};
RX   PubMed=23747412; DOI=10.1016/j.dci.2013.05.013;
RA   Lee P.T., Zou J., Holland J.W., Martin S.A., Kanellos T., Secombes C.J.;
RT   "Identification and characterization of TLR7, TLR8a2, TLR8b1 and TLR8b2
RT   genes in Atlantic salmon (Salmo salar).";
RL   Dev. Comp. Immunol. 41:295-305(2013).
RN   [2] {ECO:0000313|EMBL:CCX35460.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:CCX35460.1};
RA   Lee P.;
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:XP_013983811.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_013983811.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HF970588; CCX35460.1; -; mRNA.
DR   RefSeq; XP_013983811.1; XM_014128336.1.
DR   STRING; 8030.ENSSSAP00000057976; -.
DR   PaxDb; 8030-ENSSSAP00000057976; -.
DR   Ensembl; ENSSSAT00000087665; ENSSSAP00000057976; ENSSSAG00000054795.
DR   GeneID; 106563113; -.
DR   KEGG; sasa:106563113; -.
DR   OMA; VRPLCLE; -.
DR   OrthoDB; 4071419at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa11.
DR   Bgee; ENSSSAG00000054795; Expressed in head kidney and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR   PANTHER; PTHR47410:SF1; TOLL-LIKE RECEPTOR 8; 1.
DR   Pfam; PF13855; LRR_8; 5.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00365; LRR_SD22; 9.
DR   SMART; SM00369; LRR_TYP; 15.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 4.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:CCX35460.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..1036
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010848820"
FT   DOMAIN          870..1017
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1036 AA;  118892 MW;  BC3C6488F21A9F55 CRC64;
     MKEQHWCPLY TSFQRLLLLL VLLCLSPSCS GRTWAQRKLP CDVISLNHSL AFNCSHRKLL
     QVPHDISWNA TELDLSSNQI KILSSSSFWN LQNLTLLDLS HNFNPQEHPL KIEDQTFSML
     DQLEALLLDG NGLCTVPRGL PSGLQILFLR YNDIRTVTPE NFRDIPRIKV IRLSDNCQGS
     VCNGTLDIAN HTFSSLTNLT NLTLSFNRLK AIPHFLPPSL QLLKLERNLI THIHQHDLSA
     LTNLSALDFS GNCPVCSNTP FLCFPCNTPN GALQIHPDAF RKLSQLQELR LSGNSLEHLQ
     TTWFENLTNL RYLYLSFNRL VGEIANGDFL SVLPFVEVMD LSYNNAGQNS HNLSLSKNFS
     KLASLKTLHL ENYVFSALHK NHLEPLYSLA NLSVLNLATN FIYWTDLSLF EKFHNLSSVG
     LSENSLTFLS KRADALSVNG YGWGYEPDID RYEPLIHKDE FYRRHLPNIK PECLAYGPVL
     DLSKNNIFHI NPDMLQGLNN TACLNLSSNF IGDMFNGSEF VHFSKLKYLD LSQNKVYLRF
     EHAFSELTAL EVLDLSYNKH YFLVAGLNHS LAFLENLGSL KVLNLSWNEI STLTDKAMSS
     NSLQELNFQG NRLDIMWNKG LDFNHLFREL NNLTSLDLSY NQLHHIPSEV YDNFPKTLRH
     LTLSKNGLED FNWTRLTQLP HLEELDLSKN KLERVALTFS TLNSSLRLLD LSHNRISQLV
     PGFLRGARSL YVLDLSFNLL ELINQTTFES GAENNLQQLS LQGNPLHCTC DLLEFHMWMR
     SNEVELPLLA IEVTCDMPME RRGRSVLSYD IEECVKDDNA MAFCILTLLV VVHLLLVSLT
     AHLFYWDLSY ILYYCLAKLK HQCLLHDTDC VYDAFVMYDT TDPLASDWVL NHLRVELEER
     GERVRPLCLE ERDWMPGMPI MDNLSNSVRQ SRKTVFVLTE GFLSRGVVKM AALLVQQRLV
     EEGVDAMVLL LLQPQVLRRS RILHLRRRLC RRSVLEWPAT AGPAAQRWFW HHLKRAIRKD
     QRATHASLHG TYFTGR
//
DBGET integrated database retrieval system