ID S0J3Q1_9FIRM Unreviewed; 582 AA.
AC S0J3Q1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
GN ORFNames=C805_01552 {ECO:0000313|EMBL:EOT27444.1};
OS Eubacterium sp. 14-2.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1235790 {ECO:0000313|EMBL:EOT27444.1, ECO:0000313|Proteomes:UP000014176};
RN [1] {ECO:0000313|EMBL:EOT27444.1, ECO:0000313|Proteomes:UP000014176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=14-2 {ECO:0000313|EMBL:EOT27444.1,
RC ECO:0000313|Proteomes:UP000014176};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Eubacterium bacterium 14-2.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOT27444.1}.
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DR EMBL; ASSS01000005; EOT27444.1; -; Genomic_DNA.
DR AlphaFoldDB; S0J3Q1; -.
DR STRING; 1235790.C805_01552; -.
DR PATRIC; fig|1235790.3.peg.1652; -.
DR eggNOG; COG0534; Bacteria.
DR eggNOG; COG2172; Bacteria.
DR HOGENOM; CLU_012893_0_2_9; -.
DR OrthoDB; 1992504at2; -.
DR Proteomes; UP000014176; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002528; MATE_fam.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR Pfam; PF01554; MatE; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014176};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 463..569
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF13581"
SQ SEQUENCE 582 AA; 63738 MW; CD63889AA5EE031E CRC64;
MERNNFLINR KIHQYILPGI LMTVAVQLGN VVDGMIVGNI LGPDAMAAIE ISMPVLLLLQ
MSAMMLAMGG AAEAAVLLGK RETQKAGSVF TASLGAGLAV SLVFALFTPV LPGPLAMALS
GNETMAALVK PYIMVNFAGI PVLTAAIIFS YFMNADNHPQ LGSALFIIAN AVNLALDVLF
LQEFHMGMAG SALSTVIGYL AGMVTVAFYL RSPQRMLHLQ RPDRKLLQYA KPAARAGIPG
AAFTLISALK SVMVNSAIVR ILGNDSMAVY SVCANAVLIA ELCVGGIIGL VQNIAGILYR
ERDYCGIRTL CKRVLIYSYF AIGVLLVIFL GAPQVIAGLF GIGEGDMLEQ CKMALRIFAC
SFPFYVYNKF LMSYYQTILQ TGLSTVITVL QGFVVIVPLT LAGLLLQGLF GVCIMALVSE
AVTILLGFLY RFRGQRTGRF ETGGVYMLPQ VREEKFLECS LEDDLSKVME FREKLFVFCT
ENQIDERDAN ILGLAVEELA ANIVQYGYRG GKKNYMDIGF TIQDDKYMLR IRDDGIPFNP
MEDEQEEKEI IVGGISLLKK IMSDFQYMRV LNMNNTIVEL DR
//
